Peptide-based materials exhibit remarkable supramolecular self-assembling behavior, owing to their overwhelming propensity to from hierarchical structures from a-helices and ß-sheets. Coupling a peptide sequence to a synthetic polymer chain allows greater control over the final physical properties of the supermolecular material. So-called ‘polymer-peptide conjugates’ can be used to create biocompatible hydrogels which are held together by reversible physical interactions. Potentially, the hydrogels can be loaded with aqueous-based drug molecules, which can be injected into targeted sites in the body if they can exhibit a gel-sol-gel transition under application and removal of a shear force. In this review, we introduce this topic to readers new to the field of polymer-peptide conjugates, discussing common synthetic strategies and their self-assembling behavior. The lack of examples of actual drug delivery applications from polymer-peptide conjugates is highlighted in an attempt to incite progress in this area.
|Number of pages||22|
|Journal||Chiang Mai Journal of Science|
|Publication status||Published - Jul 2012|
- polymer-peptide conjugates
- drug delivery
Sohdi, A., Campbell, D., & Topham, P. (2012). Polymer-peptide conjugate hydrogels: towards controlled drug delivery. Chiang Mai Journal of Science, 39(3), 351-372. http://it.science.cmu.ac.th/ejournal/journalDetail.php?journal_id=1197