Polymer-peptide conjugate hydrogels: towards controlled drug delivery

Arun Sohdi, Darren Campbell, Paul Topham

Research output: Contribution to journalReview article

Abstract

Peptide-based materials exhibit remarkable supramolecular self-assembling behavior, owing to their overwhelming propensity to from hierarchical structures from a-helices and ß-sheets. Coupling a peptide sequence to a synthetic polymer chain allows greater control over the final physical properties of the supermolecular material. So-called ‘polymer-peptide conjugates’ can be used to create biocompatible hydrogels which are held together by reversible physical interactions. Potentially, the hydrogels can be loaded with aqueous-based drug molecules, which can be injected into targeted sites in the body if they can exhibit a gel-sol-gel transition under application and removal of a shear force. In this review, we introduce this topic to readers new to the field of polymer-peptide conjugates, discussing common synthetic strategies and their self-assembling behavior. The lack of examples of actual drug delivery applications from polymer-peptide conjugates is highlighted in an attempt to incite progress in this area.
Original languageEnglish
Pages (from-to)351-372
Number of pages22
JournalChiang Mai Journal of Science
Volume39
Issue number3
Publication statusPublished - Jul 2012

Fingerprint

Controlled drug delivery
Hydrogel
Drug Delivery
Hydrogels
Peptides
peptides
delivery
Polymers
drugs
polymers
Pharmaceutical Preparations
assembling
Gels
gels
Sol-gel
Polymethyl Methacrylate
readers
Helix
Hierarchical Structure
Drug delivery

Keywords

  • polymer-peptide conjugates
  • hydrogels
  • drug delivery

Cite this

Sohdi, Arun ; Campbell, Darren ; Topham, Paul. / Polymer-peptide conjugate hydrogels : towards controlled drug delivery. In: Chiang Mai Journal of Science. 2012 ; Vol. 39, No. 3. pp. 351-372.
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Polymer-peptide conjugate hydrogels : towards controlled drug delivery. / Sohdi, Arun; Campbell, Darren; Topham, Paul.

In: Chiang Mai Journal of Science, Vol. 39, No. 3, 07.2012, p. 351-372.

Research output: Contribution to journalReview article

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