Polyunsaturated fatty acids and cognitive outcomes in paediatric liver disease

Gareth Griffiths, Joel B. Talcott, Jacqueline Blyth, Jaswant Sira, Jemma Mears, Indra van Mourik, Patrick McKiernan, Sue V. Beath, Deirdre Kelly

Research output: Contribution to journalMeeting abstract

Abstract

PURPOSE: Polyunsaturated Fatty Acids (PUFAs) serve important structural and functional roles in the central nervous system, which may modulate cognitive function. This study used a liver disease and transplant (Tx) model to evaluate whether sub-optimal concentrations of PUFAs, as a result of fat malabsorption or dependence on inadequate dietary sources, is associated with PUFA deficiency and deficits in cognitive abili.METHOD: In 28 paediatric patients (14 pre-Tx, mean age 12.1; 14 post-Tx, mean age 15.0) and 11 healthy controls (mean age 12.2), erythrocyte biomarkers of fatty acid status, including the major omega-6 (linoleic and arachidonic), omega-3 (docosohexaenoic and eicosapentaenoic) fatty acids and defciency markers (osbond and mead acid), were quantifiedusing standard gas chromatography-mass spectrometry. Full-scale IQ (FSIQ) and Information Processing Speed (IPS) were assessed using standard Wechsler psychometric assessment batteries.RESULTS: Compared to controls, no signs of PUFA defciency were observed in the pre- or post-Tx groups, suggesting that: (1) neither sets of patients were deficientin their dietary intake of PUFA precursors, linoleic and alpha-linolenic acid, and (2) these patients are able to sufficientlysynthesise PUFAs from these precursors to levels comparable to controls. Strong negative correlations were observed between omega-6 fatty acids and FSIQ and IPS scores (r=-.620 and -.39; p<.001), independent of disease diagnosis and Tx (n= 39).CONCLUSION: These fndings suggest no signifcant defciency of important omega-3 fatty acids in liver disease patients. The relationship between pro-infammatory omega-6 fatty acids and FSIQ requires further investigation. Longitudinal studies of Tx patients assessing dietary intake and PUFA and IQ will help clarify the role of PUFAs in cognitive development in paediatric liver disease.
Original languageEnglish
Article number94
Pages (from-to)65
Number of pages1
JournalPediatric Transplantation
Volume15
Issue numberS1
DOIs
Publication statusPublished - 1 Aug 2011
Event6th Congress of the International Pediatric Transplant Association - Montreal, Canada
Duration: 25 Jun 201128 Jun 2011

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Unsaturated Fatty Acids
Liver Diseases
Pediatrics
Omega-6 Fatty Acids
Automatic Data Processing
Fatty Acids
alpha-Linolenic Acid
Eicosapentaenoic Acid
Omega-3 Fatty Acids
Psychometrics
Gas Chromatography-Mass Spectrometry
Cognition
Longitudinal Studies
Central Nervous System
Erythrocytes
Biomarkers
Fats
Transplants

Bibliographical note

6th Congress of the International Pediatric Transplant Association Abstracts

Cite this

Griffiths, G., Talcott, J. B., Blyth, J., Sira, J., Mears, J., van Mourik, I., ... Kelly, D. (2011). Polyunsaturated fatty acids and cognitive outcomes in paediatric liver disease. Pediatric Transplantation , 15(S1), 65. [94]. https://doi.org/10.1111/petr.2011.15.issue-s1
Griffiths, Gareth ; Talcott, Joel B. ; Blyth, Jacqueline ; Sira, Jaswant ; Mears, Jemma ; van Mourik, Indra ; McKiernan, Patrick ; Beath, Sue V. ; Kelly, Deirdre. / Polyunsaturated fatty acids and cognitive outcomes in paediatric liver disease. In: Pediatric Transplantation . 2011 ; Vol. 15, No. S1. pp. 65.
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abstract = "PURPOSE: Polyunsaturated Fatty Acids (PUFAs) serve important structural and functional roles in the central nervous system, which may modulate cognitive function. This study used a liver disease and transplant (Tx) model to evaluate whether sub-optimal concentrations of PUFAs, as a result of fat malabsorption or dependence on inadequate dietary sources, is associated with PUFA deficiency and deficits in cognitive abili.METHOD: In 28 paediatric patients (14 pre-Tx, mean age 12.1; 14 post-Tx, mean age 15.0) and 11 healthy controls (mean age 12.2), erythrocyte biomarkers of fatty acid status, including the major omega-6 (linoleic and arachidonic), omega-3 (docosohexaenoic and eicosapentaenoic) fatty acids and defciency markers (osbond and mead acid), were quantifiedusing standard gas chromatography-mass spectrometry. Full-scale IQ (FSIQ) and Information Processing Speed (IPS) were assessed using standard Wechsler psychometric assessment batteries.RESULTS: Compared to controls, no signs of PUFA defciency were observed in the pre- or post-Tx groups, suggesting that: (1) neither sets of patients were deficientin their dietary intake of PUFA precursors, linoleic and alpha-linolenic acid, and (2) these patients are able to sufficientlysynthesise PUFAs from these precursors to levels comparable to controls. Strong negative correlations were observed between omega-6 fatty acids and FSIQ and IPS scores (r=-.620 and -.39; p<.001), independent of disease diagnosis and Tx (n= 39).CONCLUSION: These fndings suggest no signifcant defciency of important omega-3 fatty acids in liver disease patients. The relationship between pro-infammatory omega-6 fatty acids and FSIQ requires further investigation. Longitudinal studies of Tx patients assessing dietary intake and PUFA and IQ will help clarify the role of PUFAs in cognitive development in paediatric liver disease.",
author = "Gareth Griffiths and Talcott, {Joel B.} and Jacqueline Blyth and Jaswant Sira and Jemma Mears and {van Mourik}, Indra and Patrick McKiernan and Beath, {Sue V.} and Deirdre Kelly",
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Griffiths, G, Talcott, JB, Blyth, J, Sira, J, Mears, J, van Mourik, I, McKiernan, P, Beath, SV & Kelly, D 2011, 'Polyunsaturated fatty acids and cognitive outcomes in paediatric liver disease', Pediatric Transplantation , vol. 15, no. S1, 94, pp. 65. https://doi.org/10.1111/petr.2011.15.issue-s1

Polyunsaturated fatty acids and cognitive outcomes in paediatric liver disease. / Griffiths, Gareth; Talcott, Joel B.; Blyth, Jacqueline; Sira, Jaswant; Mears, Jemma; van Mourik, Indra; McKiernan, Patrick; Beath, Sue V.; Kelly, Deirdre.

In: Pediatric Transplantation , Vol. 15, No. S1, 94, 01.08.2011, p. 65.

Research output: Contribution to journalMeeting abstract

TY - JOUR

T1 - Polyunsaturated fatty acids and cognitive outcomes in paediatric liver disease

AU - Griffiths, Gareth

AU - Talcott, Joel B.

AU - Blyth, Jacqueline

AU - Sira, Jaswant

AU - Mears, Jemma

AU - van Mourik, Indra

AU - McKiernan, Patrick

AU - Beath, Sue V.

AU - Kelly, Deirdre

N1 - 6th Congress of the International Pediatric Transplant Association Abstracts

PY - 2011/8/1

Y1 - 2011/8/1

N2 - PURPOSE: Polyunsaturated Fatty Acids (PUFAs) serve important structural and functional roles in the central nervous system, which may modulate cognitive function. This study used a liver disease and transplant (Tx) model to evaluate whether sub-optimal concentrations of PUFAs, as a result of fat malabsorption or dependence on inadequate dietary sources, is associated with PUFA deficiency and deficits in cognitive abili.METHOD: In 28 paediatric patients (14 pre-Tx, mean age 12.1; 14 post-Tx, mean age 15.0) and 11 healthy controls (mean age 12.2), erythrocyte biomarkers of fatty acid status, including the major omega-6 (linoleic and arachidonic), omega-3 (docosohexaenoic and eicosapentaenoic) fatty acids and defciency markers (osbond and mead acid), were quantifiedusing standard gas chromatography-mass spectrometry. Full-scale IQ (FSIQ) and Information Processing Speed (IPS) were assessed using standard Wechsler psychometric assessment batteries.RESULTS: Compared to controls, no signs of PUFA defciency were observed in the pre- or post-Tx groups, suggesting that: (1) neither sets of patients were deficientin their dietary intake of PUFA precursors, linoleic and alpha-linolenic acid, and (2) these patients are able to sufficientlysynthesise PUFAs from these precursors to levels comparable to controls. Strong negative correlations were observed between omega-6 fatty acids and FSIQ and IPS scores (r=-.620 and -.39; p<.001), independent of disease diagnosis and Tx (n= 39).CONCLUSION: These fndings suggest no signifcant defciency of important omega-3 fatty acids in liver disease patients. The relationship between pro-infammatory omega-6 fatty acids and FSIQ requires further investigation. Longitudinal studies of Tx patients assessing dietary intake and PUFA and IQ will help clarify the role of PUFAs in cognitive development in paediatric liver disease.

AB - PURPOSE: Polyunsaturated Fatty Acids (PUFAs) serve important structural and functional roles in the central nervous system, which may modulate cognitive function. This study used a liver disease and transplant (Tx) model to evaluate whether sub-optimal concentrations of PUFAs, as a result of fat malabsorption or dependence on inadequate dietary sources, is associated with PUFA deficiency and deficits in cognitive abili.METHOD: In 28 paediatric patients (14 pre-Tx, mean age 12.1; 14 post-Tx, mean age 15.0) and 11 healthy controls (mean age 12.2), erythrocyte biomarkers of fatty acid status, including the major omega-6 (linoleic and arachidonic), omega-3 (docosohexaenoic and eicosapentaenoic) fatty acids and defciency markers (osbond and mead acid), were quantifiedusing standard gas chromatography-mass spectrometry. Full-scale IQ (FSIQ) and Information Processing Speed (IPS) were assessed using standard Wechsler psychometric assessment batteries.RESULTS: Compared to controls, no signs of PUFA defciency were observed in the pre- or post-Tx groups, suggesting that: (1) neither sets of patients were deficientin their dietary intake of PUFA precursors, linoleic and alpha-linolenic acid, and (2) these patients are able to sufficientlysynthesise PUFAs from these precursors to levels comparable to controls. Strong negative correlations were observed between omega-6 fatty acids and FSIQ and IPS scores (r=-.620 and -.39; p<.001), independent of disease diagnosis and Tx (n= 39).CONCLUSION: These fndings suggest no signifcant defciency of important omega-3 fatty acids in liver disease patients. The relationship between pro-infammatory omega-6 fatty acids and FSIQ requires further investigation. Longitudinal studies of Tx patients assessing dietary intake and PUFA and IQ will help clarify the role of PUFAs in cognitive development in paediatric liver disease.

UR - http://Birmingham Children's Hospital

U2 - 10.1111/petr.2011.15.issue-s1

DO - 10.1111/petr.2011.15.issue-s1

M3 - Meeting abstract

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Griffiths G, Talcott JB, Blyth J, Sira J, Mears J, van Mourik I et al. Polyunsaturated fatty acids and cognitive outcomes in paediatric liver disease. Pediatric Transplantation . 2011 Aug 1;15(S1):65. 94. https://doi.org/10.1111/petr.2011.15.issue-s1