Keyphrases
6-mercaptopurine (6-MP)
100%
6-methylmercaptopurine
16%
6-thioguanine nucleotides
33%
Active Metabolite
33%
Acute Lymphoblastic Leukemia
100%
AIMS™
8%
Body Surface Area
33%
Controlling Factors
8%
Cytotoxic Effect
8%
Dosing Method
8%
Drug Concentration
8%
External Validation
8%
Final Model
8%
Genetic Polymorphism
8%
Genotype
25%
Highly Variable Drugs
8%
Inter-individual Variability
33%
Inter-patient
8%
Intracellular Metabolites
8%
Large Reduction
8%
Maintenance Chemotherapy
8%
Mean Parameter
8%
Metabolic Transformation
8%
Metabolism
8%
Metabolite Concentrations
8%
Modeling Program
8%
NONMEM
8%
Parameter Estimation
8%
Pediatric Patients
100%
Pharmacokinetic Model
8%
Pharmacokinetic Parameters
8%
Pharmacokinetic Variability
8%
Pharmacological Analysis
100%
Polymorphism
16%
Population Mean
8%
Population Pharmacogenetics
100%
Population Pharmacokinetic Analysis
100%
Population Pharmacokinetic Model
8%
Population Pharmacokinetics
8%
Target Dose
8%
Thiopurine Methyltransferase
33%
Treatment Outcome
8%
Pharmacology, Toxicology and Pharmaceutical Science
Active Metabolite
33%
Acute Lymphoblastic Leukemia
100%
Chemotherapy
8%
Cytotoxicity
8%
Mercaptopurine
100%
Pharmacogenetics
100%
Pharmacokinetic Parameter
8%
Pharmacokinetics
100%
Thiopurine Methyltransferase
33%
Tioguanine
33%