Populations of RNA molecules as computational model for evolution

Michael Stich, Carlos Briones, Ester Lázaro, Susanna C. Manrubia

Research output: Chapter in Book/Published conference outputChapter


We consider populations of RNA molecules as computational model for molecular evolution. Based on a large body of previous work, we review some recent results. In the first place, we study the sequence-structure map, its implications on the structural repertoire of a pool of random RNA sequences and its relevance for the RNA world hypothesis of the origin of life. In a scenario where template replication is possible, we discuss the internal organization of evolving populations and its relationship with robustness and adaptability. Finally, we explore how the effect of the mutation rate on fitness changes depends on the degree of adaptation of an RNA population.

Original languageEnglish
Title of host publicationEvolutionary Biology - Concepts, Molecular and Morphological Evolution
Subtitle of host publication13th meeting 2009
EditorsPierre Pontarotti
Place of PublicationBerlin (DE)
Number of pages13
ISBN (Electronic)978-3-642-12340-5
ISBN (Print)978-3-642-12339-9
Publication statusPublished - 2010


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