Potential role of anaerobic cocci in impaired human wound healing

Ivan B Wall, Charlotte E Davies, Katja E Hill, Melanie J Wilson, Phil Stephens, Keith G Harding, David W Thomas

Research output: Contribution to journalReview articlepeer-review


Although more than 80% of infected and 70% of noninfected leg ulcers have been shown to harbor anaerobic organisms, their role in mediating impaired wound healing in the skin is frequently overlooked. There is now increasing evidence that the gram-positive anaerobic cocci play a role (both directly and indirectly) in mediating impaired wound healing in vivo. This article discusses the mechanisms by which these microorganisms may interfere with the inflammation, repair, and remodeling phases of the wound healing process.

Original languageEnglish
Pages (from-to)346-353
Number of pages8
JournalWound Repair and Regeneration
Issue number6
Publication statusPublished - 28 Nov 2002


  • Bacteria, Anaerobic/isolation & purification
  • Gram-Positive Bacterial Infections/complications
  • Gram-Positive Cocci/isolation & purification
  • Humans
  • Leg Ulcer/complications
  • Wound Healing/physiology


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