Potential role of CXCL10/CXCR3 signaling in the development of morphine tolerance in periaqueductal gray

Wei Wang, Yawen Peng, Hui Yang, Huilian Bu, Genhua Guo, Daiqiang Liu, Bin Shu, Xuebi Tian, Ailin Luo, Xuming Zhang, Feng Gao

Research output: Contribution to journalArticle

Abstract

Tolerance to morphine antinociception hinders its long-term use in clinical practice. Interaction between neuron and microglia has been proved to play critical role in the mechanism of morphine tolerance, while CXCL10/CXCR3 signaling has been implicated in neuron-glia signaling and morphine analgesia. This study aims to investigate whether CXCL10/CXCR3 signaling in periaqueductal gray (PAG) contributes to the development of morphine tolerance by modulating neuron-microglia interaction. The results showed that the expressions of CXCR3 and CXCL10 were gradually increased in parallel with repeated morphine administration and activation of microglia. CXCR3 was co-localized with neuronal marker NeuN, while CXCL10 was derived from microglia. Microglia inhibitor minocycline significantly attenuated the expression of CXCL10, besides, both minocycline and CXCR3 inhibitor alleviated the development of morphine tolerance. Taken together, our study provided the evidence that CXCL10/CXCR3 signaling in PAG is involved in the development of morphine analgesic tolerance via neuron-microglia interaction.
Original languageEnglish
Pages (from-to)120-127
JournalNeuropeptides
Volume65
Early online date24 Jul 2017
DOIs
Publication statusPublished - 1 Oct 2017

Fingerprint

Periaqueductal Gray
Microglia
Morphine
Neurons
Minocycline
Neuroglia
Analgesia
Analgesics

Bibliographical note

© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

  • chemokine
  • CXCL10
  • CXCR3
  • morphine tolerance

Cite this

Wang, Wei ; Peng, Yawen ; Yang, Hui ; Bu, Huilian ; Guo, Genhua ; Liu, Daiqiang ; Shu, Bin ; Tian, Xuebi ; Luo, Ailin ; Zhang, Xuming ; Gao, Feng. / Potential role of CXCL10/CXCR3 signaling in the development of morphine tolerance in periaqueductal gray. In: Neuropeptides. 2017 ; Vol. 65. pp. 120-127.
@article{0d0e07f4aa004f74a52a7f1a77f70f3b,
title = "Potential role of CXCL10/CXCR3 signaling in the development of morphine tolerance in periaqueductal gray",
abstract = "Tolerance to morphine antinociception hinders its long-term use in clinical practice. Interaction between neuron and microglia has been proved to play critical role in the mechanism of morphine tolerance, while CXCL10/CXCR3 signaling has been implicated in neuron-glia signaling and morphine analgesia. This study aims to investigate whether CXCL10/CXCR3 signaling in periaqueductal gray (PAG) contributes to the development of morphine tolerance by modulating neuron-microglia interaction. The results showed that the expressions of CXCR3 and CXCL10 were gradually increased in parallel with repeated morphine administration and activation of microglia. CXCR3 was co-localized with neuronal marker NeuN, while CXCL10 was derived from microglia. Microglia inhibitor minocycline significantly attenuated the expression of CXCL10, besides, both minocycline and CXCR3 inhibitor alleviated the development of morphine tolerance. Taken together, our study provided the evidence that CXCL10/CXCR3 signaling in PAG is involved in the development of morphine analgesic tolerance via neuron-microglia interaction.",
keywords = "chemokine, CXCL10, CXCR3, morphine tolerance",
author = "Wei Wang and Yawen Peng and Hui Yang and Huilian Bu and Genhua Guo and Daiqiang Liu and Bin Shu and Xuebi Tian and Ailin Luo and Xuming Zhang and Feng Gao",
note = "{\circledC} 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/",
year = "2017",
month = "10",
day = "1",
doi = "10.1016/j.npep.2017.07.004",
language = "English",
volume = "65",
pages = "120--127",
journal = "Neuropeptides",
issn = "0143-4179",
publisher = "Churchill Livingstone",

}

Wang, W, Peng, Y, Yang, H, Bu, H, Guo, G, Liu, D, Shu, B, Tian, X, Luo, A, Zhang, X & Gao, F 2017, 'Potential role of CXCL10/CXCR3 signaling in the development of morphine tolerance in periaqueductal gray', Neuropeptides, vol. 65, pp. 120-127. https://doi.org/10.1016/j.npep.2017.07.004

Potential role of CXCL10/CXCR3 signaling in the development of morphine tolerance in periaqueductal gray. / Wang, Wei; Peng, Yawen; Yang, Hui; Bu, Huilian; Guo, Genhua; Liu, Daiqiang; Shu, Bin; Tian, Xuebi; Luo, Ailin; Zhang, Xuming; Gao, Feng.

In: Neuropeptides, Vol. 65, 01.10.2017, p. 120-127.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Potential role of CXCL10/CXCR3 signaling in the development of morphine tolerance in periaqueductal gray

AU - Wang, Wei

AU - Peng, Yawen

AU - Yang, Hui

AU - Bu, Huilian

AU - Guo, Genhua

AU - Liu, Daiqiang

AU - Shu, Bin

AU - Tian, Xuebi

AU - Luo, Ailin

AU - Zhang, Xuming

AU - Gao, Feng

N1 - © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Tolerance to morphine antinociception hinders its long-term use in clinical practice. Interaction between neuron and microglia has been proved to play critical role in the mechanism of morphine tolerance, while CXCL10/CXCR3 signaling has been implicated in neuron-glia signaling and morphine analgesia. This study aims to investigate whether CXCL10/CXCR3 signaling in periaqueductal gray (PAG) contributes to the development of morphine tolerance by modulating neuron-microglia interaction. The results showed that the expressions of CXCR3 and CXCL10 were gradually increased in parallel with repeated morphine administration and activation of microglia. CXCR3 was co-localized with neuronal marker NeuN, while CXCL10 was derived from microglia. Microglia inhibitor minocycline significantly attenuated the expression of CXCL10, besides, both minocycline and CXCR3 inhibitor alleviated the development of morphine tolerance. Taken together, our study provided the evidence that CXCL10/CXCR3 signaling in PAG is involved in the development of morphine analgesic tolerance via neuron-microglia interaction.

AB - Tolerance to morphine antinociception hinders its long-term use in clinical practice. Interaction between neuron and microglia has been proved to play critical role in the mechanism of morphine tolerance, while CXCL10/CXCR3 signaling has been implicated in neuron-glia signaling and morphine analgesia. This study aims to investigate whether CXCL10/CXCR3 signaling in periaqueductal gray (PAG) contributes to the development of morphine tolerance by modulating neuron-microglia interaction. The results showed that the expressions of CXCR3 and CXCL10 were gradually increased in parallel with repeated morphine administration and activation of microglia. CXCR3 was co-localized with neuronal marker NeuN, while CXCL10 was derived from microglia. Microglia inhibitor minocycline significantly attenuated the expression of CXCL10, besides, both minocycline and CXCR3 inhibitor alleviated the development of morphine tolerance. Taken together, our study provided the evidence that CXCL10/CXCR3 signaling in PAG is involved in the development of morphine analgesic tolerance via neuron-microglia interaction.

KW - chemokine

KW - CXCL10

KW - CXCR3

KW - morphine tolerance

UR - http://www.scopus.com/inward/record.url?scp=85025811638&partnerID=8YFLogxK

UR - https://www.sciencedirect.com/science/article/pii/S0143417917301403?via%3Dihub

U2 - 10.1016/j.npep.2017.07.004

DO - 10.1016/j.npep.2017.07.004

M3 - Article

AN - SCOPUS:85025811638

VL - 65

SP - 120

EP - 127

JO - Neuropeptides

JF - Neuropeptides

SN - 0143-4179

ER -