proteins (dArmRPs) for widespread use as protein-binding reagents, in biomedical research. These rationally designed, modular proteins bind linear target peptides in a conserved and extended conformation. Based on a designed and highly stable armadillo repeat protein, individual armadillo repeats are engineered by a combination of computational design, high-throughput mutagenesis and high throughput affinity screening to achieve single amino acid specificity. Variant repeats are then assembled according to the required target in a modular manner, ultimately to bind protein/peptide targets on demand.
|Publication status||Published - 4 May 2022|
|Event|| PEGS Boston - The essential protein engineering and cell therapy summit - Boston, Boston, United States|
Duration: 2 May 2022 → 6 May 2022
|Conference||PEGS Boston - The essential protein engineering and cell therapy summit|
|Abbreviated title||PEGS Boston 2022|
|Period||2/05/22 → 6/05/22|