Prenatal alcohol exposure and childhood balance ability: findings from a UK birth cohort study

Rachel Humphriss, Amanda Hall, Margaret May, Luisa Zuccolo, John Macleod

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To investigate the association of prenatal alcohol exposure with balance in10-year-old children.

DESIGN: Population-based prospective longitudinal study.

SETTING: Former Avon region of UK (Southwest England).

PARTICIPANTS: 6915 children from the Avon Longitudinal Study of Parents and Children who had a balance assessment at age 10 and had data on maternal alcohol consumption.

OUTCOME MEASURES: 3 composite balance scores: dynamic balance (beam-walking), static balance eyes open, static balance eyes closed (heel-to-toe balance on a beam and standing on one leg, eyes open or closed).

RESULTS: Most mothers (95.5%) consumed no-to-moderate amounts (3-7 glasses/week) of alcohol during pregnancy. Higher total-alcohol consumption was associated with maternal-social advantage, whereas binge drinking (≥4 units/day) and abstinence were associated with maternal social disadvantage. No evidence was found of an adverse effect of maternal-alcohol consumption on childhood balance. Higher maternal-alcohol use during pregnancy was generally associated with better offspring outcomes, with some specific effects appearing strong (static balance eyes open and moderate total alcohol exposure at 18 weeks, adjusted OR 1.23 (95% CI 1.01 to 1.49); static balance eyes closed and moderate total alcohol exposure at 18 weeks, adjusted OR 1.25 (95% CI 1.06 to 1.48). Similar results were found for both paternal and postnatal maternal alcohol exposure. A Mendelian-randomization approach was used to estimate the association between maternal genotype and offspring balance using the non-synonymous variant rs1229984*A (ADH1B) to proxy for lower maternal alcohol consumption; no strong associations were found between this genotype/proxy and offspring balance.

CONCLUSIONS: No evidence was found to indicate that moderate maternal alcohol consumption in this population sample had an adverse effect on offspring balance at age 10. An apparent beneficial effect of higher total maternal alcohol consumption on offspring balance appeared likely to reflect residual confounding.

Original languageEnglish
Article numbere002718
Number of pages8
JournalBMJ Open
Volume3
Issue number6
DOIs
Publication statusPublished - 17 Jun 2013

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Aptitude
Cohort Studies
Alcohols
Mothers
Parturition
Alcohol Drinking
Proxy
Longitudinal Studies
Genotype
Binge Drinking
Maternal Exposure
Pregnancy
Heel
Toes
Random Allocation
England
Population
Walking
Glass
Leg

Bibliographical note

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/3.0/ and http://creativecommons.org/licenses/by-nc/3.0/legalcode

Cite this

Humphriss, Rachel ; Hall, Amanda ; May, Margaret ; Zuccolo, Luisa ; Macleod, John. / Prenatal alcohol exposure and childhood balance ability : findings from a UK birth cohort study. In: BMJ Open. 2013 ; Vol. 3, No. 6.
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Prenatal alcohol exposure and childhood balance ability : findings from a UK birth cohort study. / Humphriss, Rachel; Hall, Amanda; May, Margaret; Zuccolo, Luisa; Macleod, John.

In: BMJ Open, Vol. 3, No. 6, e002718, 17.06.2013.

Research output: Contribution to journalArticle

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T1 - Prenatal alcohol exposure and childhood balance ability

T2 - findings from a UK birth cohort study

AU - Humphriss, Rachel

AU - Hall, Amanda

AU - May, Margaret

AU - Zuccolo, Luisa

AU - Macleod, John

N1 - This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/3.0/ and http://creativecommons.org/licenses/by-nc/3.0/legalcode

PY - 2013/6/17

Y1 - 2013/6/17

N2 - OBJECTIVE: To investigate the association of prenatal alcohol exposure with balance in10-year-old children.DESIGN: Population-based prospective longitudinal study.SETTING: Former Avon region of UK (Southwest England).PARTICIPANTS: 6915 children from the Avon Longitudinal Study of Parents and Children who had a balance assessment at age 10 and had data on maternal alcohol consumption.OUTCOME MEASURES: 3 composite balance scores: dynamic balance (beam-walking), static balance eyes open, static balance eyes closed (heel-to-toe balance on a beam and standing on one leg, eyes open or closed).RESULTS: Most mothers (95.5%) consumed no-to-moderate amounts (3-7 glasses/week) of alcohol during pregnancy. Higher total-alcohol consumption was associated with maternal-social advantage, whereas binge drinking (≥4 units/day) and abstinence were associated with maternal social disadvantage. No evidence was found of an adverse effect of maternal-alcohol consumption on childhood balance. Higher maternal-alcohol use during pregnancy was generally associated with better offspring outcomes, with some specific effects appearing strong (static balance eyes open and moderate total alcohol exposure at 18 weeks, adjusted OR 1.23 (95% CI 1.01 to 1.49); static balance eyes closed and moderate total alcohol exposure at 18 weeks, adjusted OR 1.25 (95% CI 1.06 to 1.48). Similar results were found for both paternal and postnatal maternal alcohol exposure. A Mendelian-randomization approach was used to estimate the association between maternal genotype and offspring balance using the non-synonymous variant rs1229984*A (ADH1B) to proxy for lower maternal alcohol consumption; no strong associations were found between this genotype/proxy and offspring balance.CONCLUSIONS: No evidence was found to indicate that moderate maternal alcohol consumption in this population sample had an adverse effect on offspring balance at age 10. An apparent beneficial effect of higher total maternal alcohol consumption on offspring balance appeared likely to reflect residual confounding.

AB - OBJECTIVE: To investigate the association of prenatal alcohol exposure with balance in10-year-old children.DESIGN: Population-based prospective longitudinal study.SETTING: Former Avon region of UK (Southwest England).PARTICIPANTS: 6915 children from the Avon Longitudinal Study of Parents and Children who had a balance assessment at age 10 and had data on maternal alcohol consumption.OUTCOME MEASURES: 3 composite balance scores: dynamic balance (beam-walking), static balance eyes open, static balance eyes closed (heel-to-toe balance on a beam and standing on one leg, eyes open or closed).RESULTS: Most mothers (95.5%) consumed no-to-moderate amounts (3-7 glasses/week) of alcohol during pregnancy. Higher total-alcohol consumption was associated with maternal-social advantage, whereas binge drinking (≥4 units/day) and abstinence were associated with maternal social disadvantage. No evidence was found of an adverse effect of maternal-alcohol consumption on childhood balance. Higher maternal-alcohol use during pregnancy was generally associated with better offspring outcomes, with some specific effects appearing strong (static balance eyes open and moderate total alcohol exposure at 18 weeks, adjusted OR 1.23 (95% CI 1.01 to 1.49); static balance eyes closed and moderate total alcohol exposure at 18 weeks, adjusted OR 1.25 (95% CI 1.06 to 1.48). Similar results were found for both paternal and postnatal maternal alcohol exposure. A Mendelian-randomization approach was used to estimate the association between maternal genotype and offspring balance using the non-synonymous variant rs1229984*A (ADH1B) to proxy for lower maternal alcohol consumption; no strong associations were found between this genotype/proxy and offspring balance.CONCLUSIONS: No evidence was found to indicate that moderate maternal alcohol consumption in this population sample had an adverse effect on offspring balance at age 10. An apparent beneficial effect of higher total maternal alcohol consumption on offspring balance appeared likely to reflect residual confounding.

U2 - 10.1136/bmjopen-2013-002718

DO - 10.1136/bmjopen-2013-002718

M3 - Article

C2 - 23794556

VL - 3

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

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