Preparation and characterisation of novel polycaprolactone-chitosan blends

Richard A. Rothwell*, Mark S. Pridham, Gareth A. Thomson

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

This research paper reports on the production of a biocompatible and biodegradable material to be used in a polymer stent used for counteracting the occurrence of anastomotic leakage following gastrointestinal surgery. Chitosan was blended with polycaprolactone in a solvent mixture of acetic acid and water. Membranes were formed with a range of 50/50%, 60/40%, 65/35%, 70/30% and 80/20% polycaprolactone/chitosan. The tensile properties of the blends were examined over a time period to access material degradation. In addition the biocompatibilities of the polycaprolactone/chitosan blends were tested for cytotoxic effect using primary tendon fibroblastic cells. This research concluded that the polycaprolactone/chitosan was non-toxic to the fibroblasts cells in-vitro. Analysis of the mechanical properties of the blends showed a range of mechanical strengths and polymer life spans. Overall, blends of 65/35%, 70/30% and 80/20% polycaprolactone/chitosan emerged as possible candidates for the production of a gastrointestinal stent.

Original languageEnglish
Pages (from-to)264-274
Number of pages11
JournalInternational Journal of Medical Engineering and Informatics
Volume3
Issue number3
DOIs
Publication statusPublished - Oct 2011

Keywords

  • anastomotic leakage
  • bioabsorbable
  • chitosan
  • polycaprolactone
  • stent
  • polymer stents
  • polycaprolactone-chitosan blends
  • gastrointestinal surgery
  • material degradation
  • biocompatibility
  • gastrointestinal stents

Fingerprint Dive into the research topics of 'Preparation and characterisation of novel polycaprolactone-chitosan blends'. Together they form a unique fingerprint.

  • Cite this