Preparation of 6-thioguanosine phosphoramidite for oligoribonucleotide synthesis

Yang Wang; Eric Lattmann; Qinguo Zheng

doi:10.1081/NCN-120022847

Preparation of 6-thioguanosine phosphoramidite for oligoribonucleotide synthesis

Yang Wang, Eric Lattmann, Qinguo Zheng^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

6-Thioguanosine phosphoramidite was prepared, using 2,4-dinitrophenyl as protection group for thio-function, and its stability towards conditions of RNA synthesis was investigated. The results show that the monomer was stable under the conditions of RNA synthesis and suitable for incorporation of thioguanine into oligoribonucleotides.

Original language	English
Pages (from-to)	1247-1249
Number of pages	3
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	22
Issue number	5-8
DOIs	https://doi.org/10.1081/NCN-120022847
Publication status	Published - 29 Sept 2003
Event	15th International Roundtable Meeting on Nucleosides, Nucleotides and Nucleic Acids - Leuve , Belgium Duration: 10 Sept 2002 → 14 Sept 2002

Keywords

6-Thioguanosine
modified base
modified RNA
RNA synthesis

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10.1081/NCN-120022847

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abstract = "6-Thioguanosine phosphoramidite was prepared, using 2,4-dinitrophenyl as protection group for thio-function, and its stability towards conditions of RNA synthesis was investigated. The results show that the monomer was stable under the conditions of RNA synthesis and suitable for incorporation of thioguanine into oligoribonucleotides.",

keywords = "6-Thioguanosine, modified base, modified RNA, RNA synthesis",

author = "Yang Wang and Eric Lattmann and Qinguo Zheng",

year = "2003",

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AU - Wang, Yang

AU - Lattmann, Eric

AU - Zheng, Qinguo

PY - 2003/9/29

Y1 - 2003/9/29

N2 - 6-Thioguanosine phosphoramidite was prepared, using 2,4-dinitrophenyl as protection group for thio-function, and its stability towards conditions of RNA synthesis was investigated. The results show that the monomer was stable under the conditions of RNA synthesis and suitable for incorporation of thioguanine into oligoribonucleotides.

AB - 6-Thioguanosine phosphoramidite was prepared, using 2,4-dinitrophenyl as protection group for thio-function, and its stability towards conditions of RNA synthesis was investigated. The results show that the monomer was stable under the conditions of RNA synthesis and suitable for incorporation of thioguanine into oligoribonucleotides.

KW - 6-Thioguanosine

KW - modified base

KW - modified RNA

KW - RNA synthesis

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DO - 10.1081/NCN-120022847

M3 - Article

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JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

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T2 - 15th International Roundtable Meeting on Nucleosides, Nucleotides and Nucleic Acids

Y2 - 10 September 2002 through 14 September 2002

ER -

Preparation of 6-thioguanosine phosphoramidite for oligoribonucleotide synthesis

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Keywords

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