Preparation of 6-thioguanosine phosphoramidite for oligoribonucleotide synthesis

Yang Wang, Eric Lattmann, Qinguo Zheng*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

6-Thioguanosine phosphoramidite was prepared, using 2,4-dinitrophenyl as protection group for thio-function, and its stability towards conditions of RNA synthesis was investigated. The results show that the monomer was stable under the conditions of RNA synthesis and suitable for incorporation of thioguanine into oligoribonucleotides.

Original languageEnglish
Pages (from-to)1247-1249
Number of pages3
JournalNucleosides, Nucleotides and Nucleic Acids
Volume22
Issue number5-8
DOIs
Publication statusPublished - 29 Sep 2003
Event15th International Roundtable Meeting on Nucleosides, Nucleotides and Nucleic Acids - Leuve , Belgium
Duration: 10 Sep 200214 Sep 2002

Keywords

  • 6-Thioguanosine
  • modified base
  • modified RNA
  • RNA synthesis

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