Preparation of 9-substituted pyridine-stretched adenines and hypoxanthines

Julia A. Crawford, William Fraser, Christopher A. Ramsden

Research output: Contribution to journalArticle

Abstract

9-Methylsulfanyl pyridine-stretched adenine and hypoxanthine derivatives have been prepared via regioselective reaction of a 5-aminoimidazole with 2-(bis-methylsulfanylmethylene)malononitrile [(NC)C=C(SMe) ]. The 9-methylsulfanyl substituent can be replaced by sequential oxidation and substitution by nucleophiles including amines.
Original languageEnglish
Pages (from-to)1271-1278
Number of pages8
JournalSynthesis
Volume2009
Issue number8
DOIs
Publication statusPublished - Apr 2009

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Bibliographical note

© Georg Thieme Verlag Stuttgart - New York

Keywords

  • 5-aminoimidazoles
  • lin-pyridoadenines
  • soft electrophiles
  • tricyclic heterocycles
  • pyridine-stretched purines

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