Prevalence of Virulence Genes and Associated Risk Factors of Helicobacter pylori Infection Among Adults in Gastric Cancer Risk Region of North Central, Nigeria

Azebi Ayibatari; Raphael Peter Galleh; Anowai Clementina Ogo; Abbas Abel Anzaku; Adamu Ishaku Akyala

doi:10.11648/j.ejcbs.20210706.15

Prevalence of Virulence Genes and Associated Risk Factors of Helicobacter pylori Infection Among Adults in Gastric Cancer Risk Region of North Central, Nigeria

Azebi Ayibatari, Raphael Peter Galleh, Anowai Clementina Ogo, Abbas Abel Anzaku, Adamu Ishaku Akyala

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Helicobacter pylori (H. pylori) is the causative agent of chronic gastritis and peptic ulcer diseases with associated risk factor of developing gastric cancer and mucosal-associated lymphoid tissue (MALT) lymphoma if left untreated. In this study, we evaluated the prevalence of virulence genes and associated risk factors of H. pylori among adults in a gastric cancer risk region of Nasarawa State, North central Nigeria. Methods: This was a descriptive cross-sectional study to determine H. Pylori status of 434 adults in gastric cancer high risk region of Nasarawa State from January to August, 2021. Associated risk factors and virulence genes (positive/β-(1, 3) galT of jhp0562, cagA, vacA, and hrgA) was evaluated from gastric biopsy specimens of dyspepsia patients. Results: The overall prevalence of H. pylori infection was 45.6% (198/434). The rate of infection was higher in male subjects (40.6%) than in female (23.8%); P<0.001) and higher significantly among adults with the following associated risk factors: unboil water, consumption of alcohol, low income, and Urban residency. Un-boiled water consumption and alcohol consumption were independent risk factors for H. pylori infection (odds ratio=7.48 vs OR=9.78 respectively). Of the 198 strains cultured, 76.9% carried Western-type cagA, with a higher proportion in Male (86.4%) than in Female (50.0%), P=0.05). Patients infected with East Asian-type cagA strains (P=0.027) have lesser inflammation scores in the antrum than those infected with the Western-type cagA strains. Conclusion: Our study revealed a high prevalence of H. pylori infection in Nasarawa State, with unclean water source, and alcohol consumption as significant risk factors for H. pylori infection. The incidence of gastric cancer in Nasarawa State is associated with circulating virulence genes of cagA, vacA, hrgA and jhp0562-positive/β-(1, 3) galT.

Original language	English
Pages (from-to)	118-125
Number of pages	8
Journal	European Journal of Clinical and Biomedical Sciences
Volume	7
Issue number	6
DOIs	https://doi.org/10.11648/j.ejcbs.20210706.15
Publication status	Published - 24 Nov 2021

Bibliographical note

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

virulence genes
prevalence
risk factors
helicobacter pylori
infection
gastric cancer
north central
nigeria

Access to Document

10.11648/j.ejcbs.20210706.15Licence: CC BY 4.0

Ayibatari Prevalence of Virulence Genes and Associated Risk Factors of Helicobacter pylori Infection Among Adults in Gastric Cancer Risk Region of North Central, Nigeria
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. Copyright © The Author(s), 2021. Published by Science Publishing Group
Licence: CC BY 4.0

Cite this

@article{71a0f1c8c8b4414eabff951814c7083b,

title = "Prevalence of Virulence Genes and Associated Risk Factors of Helicobacter pylori Infection Among Adults in Gastric Cancer Risk Region of North Central, Nigeria",

abstract = "Introduction: Helicobacter pylori (H. pylori) is the causative agent of chronic gastritis and peptic ulcer diseases with associated risk factor of developing gastric cancer and mucosal-associated lymphoid tissue (MALT) lymphoma if left untreated. In this study, we evaluated the prevalence of virulence genes and associated risk factors of H. pylori among adults in a gastric cancer risk region of Nasarawa State, North central Nigeria. Methods: This was a descriptive cross-sectional study to determine H. Pylori status of 434 adults in gastric cancer high risk region of Nasarawa State from January to August, 2021. Associated risk factors and virulence genes (positive/β-(1, 3) galT of jhp0562, cagA, vacA, and hrgA) was evaluated from gastric biopsy specimens of dyspepsia patients. Results: The overall prevalence of H. pylori infection was 45.6% (198/434). The rate of infection was higher in male subjects (40.6%) than in female (23.8%); P<0.001) and higher significantly among adults with the following associated risk factors: unboil water, consumption of alcohol, low income, and Urban residency. Un-boiled water consumption and alcohol consumption were independent risk factors for H. pylori infection (odds ratio=7.48 vs OR=9.78 respectively). Of the 198 strains cultured, 76.9% carried Western-type cagA, with a higher proportion in Male (86.4%) than in Female (50.0%), P=0.05). Patients infected with East Asian-type cagA strains (P=0.027) have lesser inflammation scores in the antrum than those infected with the Western-type cagA strains. Conclusion: Our study revealed a high prevalence of H. pylori infection in Nasarawa State, with unclean water source, and alcohol consumption as significant risk factors for H. pylori infection. The incidence of gastric cancer in Nasarawa State is associated with circulating virulence genes of cagA, vacA, hrgA and jhp0562-positive/β-(1, 3) galT.",

keywords = "virulence genes, prevalence, risk factors, helicobacter pylori, infection, gastric cancer, north central, nigeria",

author = "Azebi Ayibatari and Galleh, {Raphael Peter} and Ogo, {Anowai Clementina} and Anzaku, {Abbas Abel} and Akyala, {Adamu Ishaku}",

note = "This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. Copyright {\textcopyright} The Author(s), 2021. Published by Science Publishing Group",

year = "2021",

month = nov,

day = "24",

doi = "10.11648/j.ejcbs.20210706.15",

language = "English",

volume = "7",

pages = "118--125",

number = "6",

}

Prevalence of Virulence Genes and Associated Risk Factors of Helicobacter pylori Infection Among Adults in Gastric Cancer Risk Region of North Central, Nigeria. / Ayibatari, Azebi; Galleh, Raphael Peter; Ogo, Anowai Clementina et al.
In: European Journal of Clinical and Biomedical Sciences, Vol. 7, No. 6, 24.11.2021, p. 118-125.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Prevalence of Virulence Genes and Associated Risk Factors of Helicobacter pylori Infection Among Adults in Gastric Cancer Risk Region of North Central, Nigeria

AU - Ayibatari, Azebi

AU - Galleh, Raphael Peter

AU - Ogo, Anowai Clementina

AU - Anzaku, Abbas Abel

AU - Akyala, Adamu Ishaku

N1 - This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. Copyright © The Author(s), 2021. Published by Science Publishing Group

PY - 2021/11/24

Y1 - 2021/11/24

N2 - Introduction: Helicobacter pylori (H. pylori) is the causative agent of chronic gastritis and peptic ulcer diseases with associated risk factor of developing gastric cancer and mucosal-associated lymphoid tissue (MALT) lymphoma if left untreated. In this study, we evaluated the prevalence of virulence genes and associated risk factors of H. pylori among adults in a gastric cancer risk region of Nasarawa State, North central Nigeria. Methods: This was a descriptive cross-sectional study to determine H. Pylori status of 434 adults in gastric cancer high risk region of Nasarawa State from January to August, 2021. Associated risk factors and virulence genes (positive/β-(1, 3) galT of jhp0562, cagA, vacA, and hrgA) was evaluated from gastric biopsy specimens of dyspepsia patients. Results: The overall prevalence of H. pylori infection was 45.6% (198/434). The rate of infection was higher in male subjects (40.6%) than in female (23.8%); P<0.001) and higher significantly among adults with the following associated risk factors: unboil water, consumption of alcohol, low income, and Urban residency. Un-boiled water consumption and alcohol consumption were independent risk factors for H. pylori infection (odds ratio=7.48 vs OR=9.78 respectively). Of the 198 strains cultured, 76.9% carried Western-type cagA, with a higher proportion in Male (86.4%) than in Female (50.0%), P=0.05). Patients infected with East Asian-type cagA strains (P=0.027) have lesser inflammation scores in the antrum than those infected with the Western-type cagA strains. Conclusion: Our study revealed a high prevalence of H. pylori infection in Nasarawa State, with unclean water source, and alcohol consumption as significant risk factors for H. pylori infection. The incidence of gastric cancer in Nasarawa State is associated with circulating virulence genes of cagA, vacA, hrgA and jhp0562-positive/β-(1, 3) galT.

AB - Introduction: Helicobacter pylori (H. pylori) is the causative agent of chronic gastritis and peptic ulcer diseases with associated risk factor of developing gastric cancer and mucosal-associated lymphoid tissue (MALT) lymphoma if left untreated. In this study, we evaluated the prevalence of virulence genes and associated risk factors of H. pylori among adults in a gastric cancer risk region of Nasarawa State, North central Nigeria. Methods: This was a descriptive cross-sectional study to determine H. Pylori status of 434 adults in gastric cancer high risk region of Nasarawa State from January to August, 2021. Associated risk factors and virulence genes (positive/β-(1, 3) galT of jhp0562, cagA, vacA, and hrgA) was evaluated from gastric biopsy specimens of dyspepsia patients. Results: The overall prevalence of H. pylori infection was 45.6% (198/434). The rate of infection was higher in male subjects (40.6%) than in female (23.8%); P<0.001) and higher significantly among adults with the following associated risk factors: unboil water, consumption of alcohol, low income, and Urban residency. Un-boiled water consumption and alcohol consumption were independent risk factors for H. pylori infection (odds ratio=7.48 vs OR=9.78 respectively). Of the 198 strains cultured, 76.9% carried Western-type cagA, with a higher proportion in Male (86.4%) than in Female (50.0%), P=0.05). Patients infected with East Asian-type cagA strains (P=0.027) have lesser inflammation scores in the antrum than those infected with the Western-type cagA strains. Conclusion: Our study revealed a high prevalence of H. pylori infection in Nasarawa State, with unclean water source, and alcohol consumption as significant risk factors for H. pylori infection. The incidence of gastric cancer in Nasarawa State is associated with circulating virulence genes of cagA, vacA, hrgA and jhp0562-positive/β-(1, 3) galT.

KW - virulence genes

KW - prevalence

KW - risk factors

KW - helicobacter pylori

KW - infection

KW - gastric cancer

KW - north central

KW - nigeria

UR - http://dx.doi.org/10.11648/j.ejcbs.20210706.15

UR - https://www.sciencepublishinggroup.com/article/10.11648/j.ejcbs.20210706.15

U2 - 10.11648/j.ejcbs.20210706.15

DO - 10.11648/j.ejcbs.20210706.15

M3 - Article

SN - 2575-4998

VL - 7

SP - 118

EP - 125

JO - European Journal of Clinical and Biomedical Sciences

JF - European Journal of Clinical and Biomedical Sciences

IS - 6

ER -

Prevalence of Virulence Genes and Associated Risk Factors of Helicobacter pylori Infection Among Adults in Gastric Cancer Risk Region of North Central, Nigeria

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this