TY - JOUR
T1 - Pro-inflammatory cytokines IL6, TNF-α, IL1β, procalcitonin, lipopolysaccharide binding protein and C-reactive protein in infective endocarditis
AU - Watkin, R.W.
AU - Harper, L.V.
AU - Vernallis, Ann B.
AU - Lang, S.
AU - Lambert, Peter A.
AU - Ranasinghe, A.M.
AU - Elliott, Tom S.J.
PY - 2007/9
Y1 - 2007/9
N2 - Objective: To evaluate the serum levels and diagnostic value of cytokines and acute phase proteins in patients with infective endocarditis (IE). Patients and methods: Serum samples from 63 patients diagnosed with IE and 71 control patients were analysed for the following markers: interleukin-6 (IL6), tumour necrosis factor-α (TNF-α), interleukin 1-β (IL1β), procalcitonin (PCT), lipopolysaccharide binding protein (LBP) and C-reactive protein (CRP). Results: Serum levels of IL6, IL1β and CRP were significantly elevated in patients with IE as compared to controls. PCT, TNF-α and LBP were not elevated. Conclusion: Serum CRP and IL6 are elevated in IE. IL 6 may aid in establishing the diagnosis. There was no correlation between IL 6 levels and CRP, causative microorganism, echocardiographic features or outcome. © 2007 The British Infection Society.
AB - Objective: To evaluate the serum levels and diagnostic value of cytokines and acute phase proteins in patients with infective endocarditis (IE). Patients and methods: Serum samples from 63 patients diagnosed with IE and 71 control patients were analysed for the following markers: interleukin-6 (IL6), tumour necrosis factor-α (TNF-α), interleukin 1-β (IL1β), procalcitonin (PCT), lipopolysaccharide binding protein (LBP) and C-reactive protein (CRP). Results: Serum levels of IL6, IL1β and CRP were significantly elevated in patients with IE as compared to controls. PCT, TNF-α and LBP were not elevated. Conclusion: Serum CRP and IL6 are elevated in IE. IL 6 may aid in establishing the diagnosis. There was no correlation between IL 6 levels and CRP, causative microorganism, echocardiographic features or outcome. © 2007 The British Infection Society.
KW - acute phase proteins
KW - cytokines
KW - infective endocarditis
KW - inflammatory markers
UR - http://www.scopus.com/inward/record.url?scp=34547851204&partnerID=8YFLogxK
U2 - 10.1016/j.jinf.2007.05.174
DO - 10.1016/j.jinf.2007.05.174
M3 - Article
C2 - 17586049
SN - 0163-4453
VL - 55
SP - 220
EP - 225
JO - Journal of Infection
JF - Journal of Infection
IS - 3
ER -