Probing the Red Blood Cells Aggregating Force With Optical Tweezers

Kisung Lee; Anna V. Danilina; Matti Kinnunen; Alexander V. Priezzhev; Igor Meglinski

doi:10.1109/JSTQE.2015.2477396

Probing the Red Blood Cells Aggregating Force With Optical Tweezers

Kisung Lee, Anna V. Danilina, Matti Kinnunen, Alexander V. Priezzhev, Igor Meglinski

Research output: Contribution to journal › Article › peer-review

33 Citations (SciVal)

Abstract

The red blood cells (RBC) aggregation is of current basic science and clinical interest, as a determinant of blood microcirculation. Thus, the measurement and assessment of the RBC aggregation property (aggregability) and aggregation state at different physiologic conditions of a human individual or laboratory animal are an important issue. In this paper, in order to assess the dynamics of RBC interaction, optical tweezers were used to probe the forces during the RBC doublet formation or disruption. We show that in autologous plasma, RBC aggregating and disaggregating forces have different absolute values, ca 2-4 pN and dozens of piconewton, correspondingly. We speculate that in plasma, RBC aggregation and disaggregation processes have different driving forces.

Original language	English
Article number	7247655
Journal	IEEE Journal on Selected Topics in Quantum Electronics
Volume	22
Issue number	3
Early online date	9 Sept 2015
DOIs	https://doi.org/10.1109/JSTQE.2015.2477396
Publication status	Published - 1 May 2016

Funding

This work was supported by the Russian Science Foundation under Project 14-15-00602. The work of K. Lee was supported in part by the Academy of Finland under Project 279833. The work of Prof. Meglinski was supported in part by the Russian Science Foundation under project 15-14-10008.

Keywords

biological interactions
biological processes
biophotonics
biophysics
Blood
cellular biophysics

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10.1109/JSTQE.2015.2477396

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abstract = "The red blood cells (RBC) aggregation is of current basic science and clinical interest, as a determinant of blood microcirculation. Thus, the measurement and assessment of the RBC aggregation property (aggregability) and aggregation state at different physiologic conditions of a human individual or laboratory animal are an important issue. In this paper, in order to assess the dynamics of RBC interaction, optical tweezers were used to probe the forces during the RBC doublet formation or disruption. We show that in autologous plasma, RBC aggregating and disaggregating forces have different absolute values, ca 2-4 pN and dozens of piconewton, correspondingly. We speculate that in plasma, RBC aggregation and disaggregation processes have different driving forces.",

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Probing the Red Blood Cells Aggregating Force With Optical Tweezers

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