Proteomic applications of automated GPCR classification

Matthew N. Davies, David E. Gloriam, Andrew Secker, Alex A. Freitas, Miguel Mendao, Jon Timmis, Darren R. Flower

Research output: Contribution to journalArticle

Abstract

The G-protein coupled receptor (GPCR) superfamily fulfils various metabolic functions and interacts with a diverse range of ligands. There is a lack of sequence similarity between the six classes that comprise the GPCR superfamily. Moreover, most novel GPCRs found have low sequence similarity to other family members which makes it difficult to infer properties from related receptors. Many different approaches have been taken towards developing efficient and accurate methods for GPCR classification, ranging from motif-based systems to machine learning as well as a variety of alignment-free techniques based on the physiochemical properties of their amino acid sequences. This review describes the inherent difficulties in developing a GPCR classification algorithm and includes techniques previously employed in this area.
Original languageEnglish
Pages (from-to)2800-2814
Number of pages15
JournalProteomics
Volume7
Issue number16
Early online date19 Jul 2007
DOIs
Publication statusPublished - 16 Aug 2007

Fingerprint

G-Protein-Coupled Receptors
Proteomics
Learning systems
Amino Acid Sequence
Ligands
Amino Acids

Keywords

  • alignment
  • bioinformatics
  • classification
  • GPCR
  • tools

Cite this

Davies, M. N., Gloriam, D. E., Secker, A., Freitas, A. A., Mendao, M., Timmis, J., & Flower, D. R. (2007). Proteomic applications of automated GPCR classification. Proteomics, 7(16), 2800-2814. https://doi.org/10.1002/pmic.200700093
Davies, Matthew N. ; Gloriam, David E. ; Secker, Andrew ; Freitas, Alex A. ; Mendao, Miguel ; Timmis, Jon ; Flower, Darren R. / Proteomic applications of automated GPCR classification. In: Proteomics. 2007 ; Vol. 7, No. 16. pp. 2800-2814.
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Davies, MN, Gloriam, DE, Secker, A, Freitas, AA, Mendao, M, Timmis, J & Flower, DR 2007, 'Proteomic applications of automated GPCR classification', Proteomics, vol. 7, no. 16, pp. 2800-2814. https://doi.org/10.1002/pmic.200700093

Proteomic applications of automated GPCR classification. / Davies, Matthew N.; Gloriam, David E.; Secker, Andrew; Freitas, Alex A.; Mendao, Miguel; Timmis, Jon; Flower, Darren R.

In: Proteomics, Vol. 7, No. 16, 16.08.2007, p. 2800-2814.

Research output: Contribution to journalArticle

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Davies MN, Gloriam DE, Secker A, Freitas AA, Mendao M, Timmis J et al. Proteomic applications of automated GPCR classification. Proteomics. 2007 Aug 16;7(16):2800-2814. https://doi.org/10.1002/pmic.200700093