Proteomics in cardiovascular diseases: Unveiling sex and gender differences in the era of precision medicine

Roberta Baetta, Marta Pontremoli, Alma Martinez Fernandez, Corinne M. Spickett, Cristina Banfi

Research output: Contribution to journalArticle

Abstract

Cardiovascular diseases (CVDs) represent the most important cause of mortality in women and in men. Contrary to the long-standing notion that the effects of the major risk factors on CVD outcomes are the same in both sexes, recent evidence recognizes new, potentially independent, sex/gender-related risk factors for CVDs, and sex/gender-differences in the clinical presentation of CVDs have been demonstrated. Furthermore, some therapeutic options may not be equally effective and safe in men and women. In this context, proteomics offers an extremely useful and versatile analytical platform for biomedical researches that expand from the screening of early diagnostic and prognostic biomarkers to the investigation of the molecular mechanisms underlying CDVs. In this review, we summarized the current applications of proteomics in the cardiovascular field, with emphasis on sex and gender-related differences in CVDs.

Significance

Increasing evidence supports the profound effect of sex and gender on cardiovascular physio-pathology and the response to drugs. A clear understanding of the mechanisms underlying sexual dimorphisms in CVDs would not only improve our knowledge of the etiology of these diseases, but could also inform health policy makers and guideline committees in tailoring specific interventions for the prevention, treatment and management of CVDs in both men and women.
LanguageEnglish
JournalJournal of Proteomics
VolumeEarly online
Early online date24 Nov 2017
DOIs
Publication statusE-pub ahead of print - 24 Nov 2017

Fingerprint

Precision Medicine
Sex Characteristics
Proteomics
Medicine
Cardiovascular Diseases
Health Policy
Administrative Personnel
Biomarkers
Pathology
Biomedical Research
Screening
Guidelines
Health
Mortality
Therapeutics
Pharmaceutical Preparations

Bibliographical note

© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/

Funding: European Union’s Horizon 2020 research and innovation
programme under the Marie Sklodowska-Curie grant agreement number 675132

Keywords

  • Sex differences
  • Gender
  • Cardiovascular disease
  • Risk factors
  • Oxidative stress
  • Proteomics

Cite this

Baetta, Roberta ; Pontremoli, Marta ; Fernandez, Alma Martinez ; Spickett, Corinne M. ; Banfi, Cristina. / Proteomics in cardiovascular diseases: Unveiling sex and gender differences in the era of precision medicine. In: Journal of Proteomics. 2017 ; Vol. Early online.
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Proteomics in cardiovascular diseases: Unveiling sex and gender differences in the era of precision medicine. / Baetta, Roberta; Pontremoli, Marta; Fernandez, Alma Martinez; Spickett, Corinne M.; Banfi, Cristina.

In: Journal of Proteomics, Vol. Early online, 24.11.2017.

Research output: Contribution to journalArticle

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