Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy

Jon Genuneit; Sashini Jayasinghe; Carmen Riggioni; Rachel Louise Peters; Derek K. Chu; Daniel Munblit; Robert J. Boyle; George Du Toit; Isabel Skypala; Alexandra F. Santos; Cezmi A. Akdis; Alberto Alvarez-Perea; Montserrat Alvaro Lozano; Riccardo Asero; Barbara Ballmer-Weber; Domingo Barber; Simona Barni; Giovanni Battista Pajno; Kirsten Beyer; Carsten Bindslev-Jensen; Helen Brough; Betul Buyuktiryaki; Lucila Camargo Lopes de Oliveira; Antonella Cianferoni; R. Sharon Chinthrajah; Sean N. Parker; Stefano Del Giacco; Audrey DunnGalvin; Bernadette Eberlein; Motohiro Ebisawa; Philippe Eigenmann; Thomas Eiwegger; Margaretha Faber; Montserrat Fernandez-Rivas; Mary Feeney; Helen Fisher; Mattia Giovannini; Susanne Halken; Karin Hoffmann-Sommergruber; Hannah Jaumdally; Christina J. Jones; Rebecca Knibb; Edward Knol; George N. Konstantinou; Marta Krawiec; Susanne Lau; Lina Mayorga; M. Andreina Marques-Mejias; Rosan Meyer; Beatriz Moya

doi:10.1111/pai.13684

Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy

Jon Genuneit^*, Sashini Jayasinghe, Carmen Riggioni, Rachel Louise Peters, Derek K. Chu, Daniel Munblit, Robert J. Boyle, George Du Toit, Isabel Skypala, Alexandra F. Santos, Cezmi A. Akdis, Alberto Alvarez-Perea, Montserrat Alvaro Lozano, Riccardo Asero, Barbara Ballmer-Weber, Domingo Barber, Simona Barni, Giovanni Battista Pajno, Kirsten Beyer, Carsten Bindslev-JensenHelen Brough, Betul Buyuktiryaki, Lucila Camargo Lopes de Oliveira, Antonella Cianferoni, R. Sharon Chinthrajah, Sean N. Parker, Stefano Del Giacco, Audrey DunnGalvin, Bernadette Eberlein, Motohiro Ebisawa, Philippe Eigenmann, Thomas Eiwegger, Margaretha Faber, Montserrat Fernandez-Rivas, Mary Feeney, Helen Fisher, Mattia Giovannini, Susanne Halken, Karin Hoffmann-Sommergruber, Hannah Jaumdally, Christina J. Jones, Rebecca Knibb, Edward Knol, George N. Konstantinou, Marta Krawiec, Susanne Lau, Lina Mayorga, M. Andreina Marques-Mejias, Rosan Meyer, Beatriz Moya,

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of updating the guidelines on the diagnosis and management of food allergy. The existing guidelines are based on a systematic review of the literature until 30 September 2012. Therefore, a new systematic review must be undertaken to inform the new guidelines. This systematic review aims to assess the accuracy of index tests to support the diagnosis of IgE-mediated food allergy. Methods: The databases Cochrane CENTRAL (Trials), MEDLINE (OVID) and Embase (OVID) will be searched for diagnostic test accuracy studies from 1 October 2012 to 30 June 2021. Inclusion and exclusion criteria will be used to select appropriate studies. Data from these studies will be extracted and tabulated, and then reviewed for risk of bias and applicability using the QUADAS-2 tool. All evaluations will be done in duplicate. Studies with a high risk of bias and low applicability will be excluded. Meta-analysis will be performed if there are three or more studies of the same index test and food. Results: A protocol for the systematic review and meta-analyses is presented and was registered using Prospero prior to commencing the literature search. Discussion: Oral food challenges are the reference standard for diagnosis but involve considerable risks and resources. This protocol for systematic review aims to assess the accuracy of various tests to diagnose food allergy, which can be useful in both clinical and research settings.

Original language	English
Article number	e13684
Journal	Pediatric Allergy and Immunology
Volume	33
Issue number	1
Early online date	21 Oct 2021
DOIs	https://doi.org/10.1111/pai.13684
Publication status	Published - Jan 2022

Bibliographical note

The submitted version available at 10.22541/au.162677307.71576556/v1 was accepted for publication on 9 Sept 2021.

The final published version can be found at:
Genuneit, J, Jayasinghe, S, Riggioni, C, et al; on behalf of the EAACI Food Allergy Guidelines Expert Group, the EAACI Research, Outreach Committee Food Allergy Group. Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy. Pediatr Allergy Immunol. 2021; 00: 1– 8. https://doi.org/10.1111/pai.13684

Keywords

basophil activation test
component-resolved diagnostics
diagnosis
diagnostic tests
food allergy
IgE-mediated
mast cell activation test
skin prick test
specific IgE

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Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergySubmitted manuscript, 204 KB

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Genuneit, J., Jayasinghe, S., Riggioni, C., Peters, R. L., Chu, D. K., Munblit, D., Boyle, R. J., Du Toit, G., Skypala, I., Santos, A. F., Akdis, C. A., Alvarez-Perea, A., Lozano, M. A., Asero, R., Ballmer-Weber, B., Barber, D., Barni, S., Pajno, G. B., Beyer, K. (2022). Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy. Pediatric Allergy and Immunology, 33(1), Article e13684. https://doi.org/10.1111/pai.13684

@article{886b75dc80c84f81926f84319758d273,

title = "Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy",

abstract = "Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of updating the guidelines on the diagnosis and management of food allergy. The existing guidelines are based on a systematic review of the literature until 30 September 2012. Therefore, a new systematic review must be undertaken to inform the new guidelines. This systematic review aims to assess the accuracy of index tests to support the diagnosis of IgE-mediated food allergy. Methods: The databases Cochrane CENTRAL (Trials), MEDLINE (OVID) and Embase (OVID) will be searched for diagnostic test accuracy studies from 1 October 2012 to 30 June 2021. Inclusion and exclusion criteria will be used to select appropriate studies. Data from these studies will be extracted and tabulated, and then reviewed for risk of bias and applicability using the QUADAS-2 tool. All evaluations will be done in duplicate. Studies with a high risk of bias and low applicability will be excluded. Meta-analysis will be performed if there are three or more studies of the same index test and food. Results: A protocol for the systematic review and meta-analyses is presented and was registered using Prospero prior to commencing the literature search. Discussion: Oral food challenges are the reference standard for diagnosis but involve considerable risks and resources. This protocol for systematic review aims to assess the accuracy of various tests to diagnose food allergy, which can be useful in both clinical and research settings.",

keywords = "basophil activation test, component-resolved diagnostics, diagnosis, diagnostic tests, food allergy, IgE-mediated, mast cell activation test, skin prick test, specific IgE",

author = "Jon Genuneit and Sashini Jayasinghe and Carmen Riggioni and Peters, {Rachel Louise} and Chu, {Derek K.} and Daniel Munblit and Boyle, {Robert J.} and {Du Toit}, George and Isabel Skypala and Santos, {Alexandra F.} and Akdis, {Cezmi A.} and Alberto Alvarez-Perea and Lozano, {Montserrat Alvaro} and Riccardo Asero and Barbara Ballmer-Weber and Domingo Barber and Simona Barni and Pajno, {Giovanni Battista} and Kirsten Beyer and Carsten Bindslev-Jensen and Helen Brough and Betul Buyuktiryaki and {de Oliveira}, {Lucila Camargo Lopes} and Antonella Cianferoni and Chinthrajah, {R. Sharon} and Parker, {Sean N.} and Giacco, {Stefano Del} and Audrey DunnGalvin and Bernadette Eberlein and Motohiro Ebisawa and Philippe Eigenmann and Thomas Eiwegger and Margaretha Faber and Montserrat Fernandez-Rivas and Mary Feeney and Helen Fisher and Mattia Giovannini and Susanne Halken and Karin Hoffmann-Sommergruber and Hannah Jaumdally and Jones, {Christina J.} and Rebecca Knibb and Edward Knol and Konstantinou, {George N.} and Marta Krawiec and Susanne Lau and Lina Mayorga and Marques-Mejias, {M. Andreina} and Rosan Meyer and Beatriz Moya",

note = "The submitted version available at 10.22541/au.162677307.71576556/v1 was accepted for publication on 9 Sept 2021. The final published version can be found at: Genuneit, J, Jayasinghe, S, Riggioni, C, et al; on behalf of the EAACI Food Allergy Guidelines Expert Group, the EAACI Research, Outreach Committee Food Allergy Group. Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy. Pediatr Allergy Immunol. 2021; 00: 1– 8. https://doi.org/10.1111/pai.13684 ",

year = "2022",

month = jan,

doi = "10.1111/pai.13684",

language = "English",

volume = "33",

journal = "Pediatric Allergy and Immunology",

issn = "0905-6157",

publisher = "Blackwell",

number = "1",

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Genuneit, J, Jayasinghe, S, Riggioni, C, Peters, RL, Chu, DK, Munblit, D, Boyle, RJ, Du Toit, G, Skypala, I, Santos, AF, Akdis, CA, Alvarez-Perea, A, Lozano, MA, Asero, R, Ballmer-Weber, B, Barber, D, Barni, S, Pajno, GB, Beyer, K, Bindslev-Jensen, C, Brough, H, Buyuktiryaki, B, de Oliveira, LCL, Cianferoni, A, Chinthrajah, RS, Parker, SN, Giacco, SD, DunnGalvin, A, Eberlein, B, Ebisawa, M, Eigenmann, P, Eiwegger, T, Faber, M, Fernandez-Rivas, M, Feeney, M, Fisher, H, Giovannini, M, Halken, S, Hoffmann-Sommergruber, K, Jaumdally, H, Jones, CJ, Knibb, R, Knol, E, Konstantinou, GN, Krawiec, M, Lau, S, Mayorga, L, Marques-Mejias, MA, Meyer, R, Moya, B 2022, 'Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy', Pediatric Allergy and Immunology, vol. 33, no. 1, e13684. https://doi.org/10.1111/pai.13684

TY - JOUR

T1 - Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy

AU - Genuneit, Jon

AU - Jayasinghe, Sashini

AU - Riggioni, Carmen

AU - Peters, Rachel Louise

AU - Chu, Derek K.

AU - Munblit, Daniel

AU - Boyle, Robert J.

AU - Du Toit, George

AU - Skypala, Isabel

AU - Santos, Alexandra F.

AU - Akdis, Cezmi A.

AU - Alvarez-Perea, Alberto

AU - Lozano, Montserrat Alvaro

AU - Asero, Riccardo

AU - Ballmer-Weber, Barbara

AU - Barber, Domingo

AU - Barni, Simona

AU - Pajno, Giovanni Battista

AU - Beyer, Kirsten

AU - Bindslev-Jensen, Carsten

AU - Brough, Helen

AU - Buyuktiryaki, Betul

AU - de Oliveira, Lucila Camargo Lopes

AU - Cianferoni, Antonella

AU - Chinthrajah, R. Sharon

AU - Parker, Sean N.

AU - Giacco, Stefano Del

AU - DunnGalvin, Audrey

AU - Eberlein, Bernadette

AU - Ebisawa, Motohiro

AU - Eigenmann, Philippe

AU - Eiwegger, Thomas

AU - Faber, Margaretha

AU - Fernandez-Rivas, Montserrat

AU - Feeney, Mary

AU - Fisher, Helen

AU - Giovannini, Mattia

AU - Halken, Susanne

AU - Hoffmann-Sommergruber, Karin

AU - Jaumdally, Hannah

AU - Jones, Christina J.

AU - Knibb, Rebecca

AU - Knol, Edward

AU - Konstantinou, George N.

AU - Krawiec, Marta

AU - Lau, Susanne

AU - Mayorga, Lina

AU - Marques-Mejias, M. Andreina

AU - Meyer, Rosan

AU - Moya, Beatriz

N1 - The submitted version available at 10.22541/au.162677307.71576556/v1 was accepted for publication on 9 Sept 2021. The final published version can be found at: Genuneit, J, Jayasinghe, S, Riggioni, C, et al; on behalf of the EAACI Food Allergy Guidelines Expert Group, the EAACI Research, Outreach Committee Food Allergy Group. Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy. Pediatr Allergy Immunol. 2021; 00: 1– 8. https://doi.org/10.1111/pai.13684

PY - 2022/1

Y1 - 2022/1

N2 - Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of updating the guidelines on the diagnosis and management of food allergy. The existing guidelines are based on a systematic review of the literature until 30 September 2012. Therefore, a new systematic review must be undertaken to inform the new guidelines. This systematic review aims to assess the accuracy of index tests to support the diagnosis of IgE-mediated food allergy. Methods: The databases Cochrane CENTRAL (Trials), MEDLINE (OVID) and Embase (OVID) will be searched for diagnostic test accuracy studies from 1 October 2012 to 30 June 2021. Inclusion and exclusion criteria will be used to select appropriate studies. Data from these studies will be extracted and tabulated, and then reviewed for risk of bias and applicability using the QUADAS-2 tool. All evaluations will be done in duplicate. Studies with a high risk of bias and low applicability will be excluded. Meta-analysis will be performed if there are three or more studies of the same index test and food. Results: A protocol for the systematic review and meta-analyses is presented and was registered using Prospero prior to commencing the literature search. Discussion: Oral food challenges are the reference standard for diagnosis but involve considerable risks and resources. This protocol for systematic review aims to assess the accuracy of various tests to diagnose food allergy, which can be useful in both clinical and research settings.

AB - Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of updating the guidelines on the diagnosis and management of food allergy. The existing guidelines are based on a systematic review of the literature until 30 September 2012. Therefore, a new systematic review must be undertaken to inform the new guidelines. This systematic review aims to assess the accuracy of index tests to support the diagnosis of IgE-mediated food allergy. Methods: The databases Cochrane CENTRAL (Trials), MEDLINE (OVID) and Embase (OVID) will be searched for diagnostic test accuracy studies from 1 October 2012 to 30 June 2021. Inclusion and exclusion criteria will be used to select appropriate studies. Data from these studies will be extracted and tabulated, and then reviewed for risk of bias and applicability using the QUADAS-2 tool. All evaluations will be done in duplicate. Studies with a high risk of bias and low applicability will be excluded. Meta-analysis will be performed if there are three or more studies of the same index test and food. Results: A protocol for the systematic review and meta-analyses is presented and was registered using Prospero prior to commencing the literature search. Discussion: Oral food challenges are the reference standard for diagnosis but involve considerable risks and resources. This protocol for systematic review aims to assess the accuracy of various tests to diagnose food allergy, which can be useful in both clinical and research settings.

KW - basophil activation test

KW - component-resolved diagnostics

KW - diagnosis

KW - diagnostic tests

KW - food allergy

KW - IgE-mediated

KW - mast cell activation test

KW - skin prick test

KW - specific IgE

UR - http://www.scopus.com/inward/record.url?scp=85118650786&partnerID=8YFLogxK

U2 - 10.1111/pai.13684

DO - 10.1111/pai.13684

M3 - Article

AN - SCOPUS:85118650786

SN - 0905-6157

VL - 33

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

IS - 1

M1 - e13684

ER -

Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy

Abstract

Bibliographical note

Keywords

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