TY - JOUR
T1 - Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation
AU - Myllylä, Teemu
AU - Vihriälä, Erkki
AU - Pedone, Matteo
AU - Korhonen, Vesa
AU - Surazynski, Lukasz
AU - Wróbel, Maciej
AU - Zienkiewicz, Aleksandra
AU - Hakala, Jaakko
AU - Sorvoja, Hannu
AU - Lauri, Janne
AU - Fabritius, Tapio
AU - Jȩdrzejewska-Szczerska, Małgorzata
AU - Kiviniemi, Vesa
AU - Meglinski, Igor
N1 - Copyright 2017 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
PY - 2017/3/3
Y1 - 2017/3/3
N2 - In brain studies, the function of the cerebrospinal fluid (CSF) awakes growing interest, particularly related to studies of the glymphatic system in the brain, which is connected with the complex system of lymphatic vessels responsible for cleaning the tissues. The CSF is a clear, colourless liquid including water (H2O) approximately with a concentration of 99 %. In addition, it contains electrolytes, amino acids, glucose, and other small molecules found in plasma. The CSF acts as a cushion behind the skull, providing basic mechanical as well as immunological protection to the brain. Disturbances of the CSF circulation have been linked to several brain related medical disorders, such as dementia. Our goal is to develop an in vivo method for the non-invasive measurement of cerebral blood flow and CSF circulation by exploiting optical and capacitive sensing techniques simultaneously. We introduce a prototype of a wearable probe that is aimed to be used for long-term brain monitoring purposes, especially focusing on studies of the glymphatic system. In this method, changes in cerebral blood flow, particularly oxy- and deoxyhaemoglobin, are measured simultaneously and analysed with the response gathered by the capacitive sensor in order to distinct the dynamics of the CSF circulation behind the skull. Presented prototype probe is tested by measuring liquid flows inside phantoms mimicking the CSF circulation.
AB - In brain studies, the function of the cerebrospinal fluid (CSF) awakes growing interest, particularly related to studies of the glymphatic system in the brain, which is connected with the complex system of lymphatic vessels responsible for cleaning the tissues. The CSF is a clear, colourless liquid including water (H2O) approximately with a concentration of 99 %. In addition, it contains electrolytes, amino acids, glucose, and other small molecules found in plasma. The CSF acts as a cushion behind the skull, providing basic mechanical as well as immunological protection to the brain. Disturbances of the CSF circulation have been linked to several brain related medical disorders, such as dementia. Our goal is to develop an in vivo method for the non-invasive measurement of cerebral blood flow and CSF circulation by exploiting optical and capacitive sensing techniques simultaneously. We introduce a prototype of a wearable probe that is aimed to be used for long-term brain monitoring purposes, especially focusing on studies of the glymphatic system. In this method, changes in cerebral blood flow, particularly oxy- and deoxyhaemoglobin, are measured simultaneously and analysed with the response gathered by the capacitive sensor in order to distinct the dynamics of the CSF circulation behind the skull. Presented prototype probe is tested by measuring liquid flows inside phantoms mimicking the CSF circulation.
KW - brain
KW - capacitive sensing
KW - cerebrospinal fluid
KW - optical methods
KW - opto-capacitive probe
UR - http://www.scopus.com/inward/record.url?scp=85019210503&partnerID=8YFLogxK
UR - https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10063/1/Prototype-of-an-opto-capacitive-probe-for-non-invasive-sensing/10.1117/12.2251977.full
U2 - 10.1117/12.2251977
DO - 10.1117/12.2251977
M3 - Conference article
AN - SCOPUS:85019210503
SN - 0277-786X
VL - 10063
JO - Proceedings of SPIE - International Society for Optical Engineering
JF - Proceedings of SPIE - International Society for Optical Engineering
M1 - 100630M
T2 - Dynamics and Fluctuations in Biomedical Photonics XIV
Y2 - 29 January 2017 through 30 January 2017
ER -