Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation

Teemu Myllylä; Erkki Vihriälä; Matteo Pedone; Vesa Korhonen; Lukasz Surazynski; Maciej Wróbel; Aleksandra Zienkiewicz; Jaakko Hakala; Hannu Sorvoja; Janne Lauri; Tapio Fabritius; Małgorzata Jȩdrzejewska-Szczerska; Vesa Kiviniemi; Igor Meglinski

doi:10.1117/12.2251977

Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation

Teemu Myllylä, Erkki Vihriälä, Matteo Pedone, Vesa Korhonen, Lukasz Surazynski, Maciej Wróbel, Aleksandra Zienkiewicz, Jaakko Hakala, Hannu Sorvoja, Janne Lauri, Tapio Fabritius, Małgorzata Jȩdrzejewska-Szczerska, Vesa Kiviniemi, Igor Meglinski

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Abstract

In brain studies, the function of the cerebrospinal fluid (CSF) awakes growing interest, particularly related to studies of the glymphatic system in the brain, which is connected with the complex system of lymphatic vessels responsible for cleaning the tissues. The CSF is a clear, colourless liquid including water (H2O) approximately with a concentration of 99 %. In addition, it contains electrolytes, amino acids, glucose, and other small molecules found in plasma. The CSF acts as a cushion behind the skull, providing basic mechanical as well as immunological protection to the brain. Disturbances of the CSF circulation have been linked to several brain related medical disorders, such as dementia. Our goal is to develop an in vivo method for the non-invasive measurement of cerebral blood flow and CSF circulation by exploiting optical and capacitive sensing techniques simultaneously. We introduce a prototype of a wearable probe that is aimed to be used for long-term brain monitoring purposes, especially focusing on studies of the glymphatic system. In this method, changes in cerebral blood flow, particularly oxy- and deoxyhaemoglobin, are measured simultaneously and analysed with the response gathered by the capacitive sensor in order to distinct the dynamics of the CSF circulation behind the skull. Presented prototype probe is tested by measuring liquid flows inside phantoms mimicking the CSF circulation.

Original language	English
Article number	100630M
Journal	Proceedings of SPIE - International Society for Optical Engineering
Volume	10063
DOIs	https://doi.org/10.1117/12.2251977
Publication status	Published - 3 Mar 2017
Event	Dynamics and Fluctuations in Biomedical Photonics XIV - San Francisco, United States Duration: 29 Jan 2017 → 30 Jan 2017

Bibliographical note

Copyright 2017 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

Funding

This study was partially funded by European Regional Development Fund, coordinated by Centre for Health and Technology, Oulu, Finland; and by Academy of Finland & JAES-grants. M.S. W. and M. J-Sz acknowledge the support of the National Science Center, Poland, grant no. 2016/20/T/ST7/00380, as well as DS Programs of the Faculty of Electronics, Telecommunications and Informatics, Gda?sk University of Technology. EU COST BM1205 Action "Skin Cancer Laser Imaging".

Keywords

brain
capacitive sensing
cerebrospinal fluid
optical methods
opto-capacitive probe

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Myllylä, T., Vihriälä, E., Pedone, M., Korhonen, V., Surazynski, L., Wróbel, M., Zienkiewicz, A., Hakala, J., Sorvoja, H., Lauri, J., Fabritius, T., Jȩdrzejewska-Szczerska, M., Kiviniemi, V., & Meglinski, I. (2017). Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation. Proceedings of SPIE - International Society for Optical Engineering, 10063, Article 100630M. https://doi.org/10.1117/12.2251977

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abstract = "In brain studies, the function of the cerebrospinal fluid (CSF) awakes growing interest, particularly related to studies of the glymphatic system in the brain, which is connected with the complex system of lymphatic vessels responsible for cleaning the tissues. The CSF is a clear, colourless liquid including water (H2O) approximately with a concentration of 99 %. In addition, it contains electrolytes, amino acids, glucose, and other small molecules found in plasma. The CSF acts as a cushion behind the skull, providing basic mechanical as well as immunological protection to the brain. Disturbances of the CSF circulation have been linked to several brain related medical disorders, such as dementia. Our goal is to develop an in vivo method for the non-invasive measurement of cerebral blood flow and CSF circulation by exploiting optical and capacitive sensing techniques simultaneously. We introduce a prototype of a wearable probe that is aimed to be used for long-term brain monitoring purposes, especially focusing on studies of the glymphatic system. In this method, changes in cerebral blood flow, particularly oxy- and deoxyhaemoglobin, are measured simultaneously and analysed with the response gathered by the capacitive sensor in order to distinct the dynamics of the CSF circulation behind the skull. Presented prototype probe is tested by measuring liquid flows inside phantoms mimicking the CSF circulation.",

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Myllylä, T, Vihriälä, E, Pedone, M, Korhonen, V, Surazynski, L, Wróbel, M, Zienkiewicz, A, Hakala, J, Sorvoja, H, Lauri, J, Fabritius, T, Jȩdrzejewska-Szczerska, M, Kiviniemi, V & Meglinski, I 2017, 'Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation', Proceedings of SPIE - International Society for Optical Engineering, vol. 10063, 100630M. https://doi.org/10.1117/12.2251977

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AU - Myllylä, Teemu

AU - Vihriälä, Erkki

AU - Pedone, Matteo

AU - Korhonen, Vesa

AU - Surazynski, Lukasz

AU - Wróbel, Maciej

AU - Zienkiewicz, Aleksandra

AU - Hakala, Jaakko

AU - Sorvoja, Hannu

AU - Lauri, Janne

AU - Fabritius, Tapio

AU - Jȩdrzejewska-Szczerska, Małgorzata

AU - Kiviniemi, Vesa

AU - Meglinski, Igor

N1 - Copyright 2017 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

PY - 2017/3/3

Y1 - 2017/3/3

N2 - In brain studies, the function of the cerebrospinal fluid (CSF) awakes growing interest, particularly related to studies of the glymphatic system in the brain, which is connected with the complex system of lymphatic vessels responsible for cleaning the tissues. The CSF is a clear, colourless liquid including water (H2O) approximately with a concentration of 99 %. In addition, it contains electrolytes, amino acids, glucose, and other small molecules found in plasma. The CSF acts as a cushion behind the skull, providing basic mechanical as well as immunological protection to the brain. Disturbances of the CSF circulation have been linked to several brain related medical disorders, such as dementia. Our goal is to develop an in vivo method for the non-invasive measurement of cerebral blood flow and CSF circulation by exploiting optical and capacitive sensing techniques simultaneously. We introduce a prototype of a wearable probe that is aimed to be used for long-term brain monitoring purposes, especially focusing on studies of the glymphatic system. In this method, changes in cerebral blood flow, particularly oxy- and deoxyhaemoglobin, are measured simultaneously and analysed with the response gathered by the capacitive sensor in order to distinct the dynamics of the CSF circulation behind the skull. Presented prototype probe is tested by measuring liquid flows inside phantoms mimicking the CSF circulation.

AB - In brain studies, the function of the cerebrospinal fluid (CSF) awakes growing interest, particularly related to studies of the glymphatic system in the brain, which is connected with the complex system of lymphatic vessels responsible for cleaning the tissues. The CSF is a clear, colourless liquid including water (H2O) approximately with a concentration of 99 %. In addition, it contains electrolytes, amino acids, glucose, and other small molecules found in plasma. The CSF acts as a cushion behind the skull, providing basic mechanical as well as immunological protection to the brain. Disturbances of the CSF circulation have been linked to several brain related medical disorders, such as dementia. Our goal is to develop an in vivo method for the non-invasive measurement of cerebral blood flow and CSF circulation by exploiting optical and capacitive sensing techniques simultaneously. We introduce a prototype of a wearable probe that is aimed to be used for long-term brain monitoring purposes, especially focusing on studies of the glymphatic system. In this method, changes in cerebral blood flow, particularly oxy- and deoxyhaemoglobin, are measured simultaneously and analysed with the response gathered by the capacitive sensor in order to distinct the dynamics of the CSF circulation behind the skull. Presented prototype probe is tested by measuring liquid flows inside phantoms mimicking the CSF circulation.

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KW - optical methods

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Y2 - 29 January 2017 through 30 January 2017

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Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation

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