Quantitative differences in beta/A4 protein subtypes in the parahippocampal gyrus and frontal cortex in Alzheimer's disease

Richard A. Armstrong

Research output: Contribution to journalArticle

Abstract

The density of diffuse, primitive and classic beta/A4 protein deposits was estimated in sulci and gyri in the frontal cortex and parahippocampal gyrus (PHG) in 8 cases of Alzheimer's disease. Total beta/A4 deposit density was similar in the frontal cortex and PHG but the ratio of primitive and classic deposits to the total was greater in the PHG compared with the frontal cortex. Total beta/A4 deposit density was greater in the depths of the sulci, but the proportions of the various beta/A4 subtypes were similar in sulci and gyri. Hence, increased density of primitive and classic deposits in the PHG could reflect enhanced conversion of diffuse to mature deposits whereas increased density of mature beta/A4 subtypes in sulci versus gyri may reflect increased beta/A4 deposition in the sulci.
Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalDementia and Geriatric Cognitive Disorders
Volume5
Issue number1
DOIs
Publication statusPublished - 1994

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Parahippocampal Gyrus
Frontal Lobe
Alzheimer Disease
Proteins

Keywords

  • Alzheimer's disease
  • beta/A4 protein deposition
  • amyloid
  • frontal cortex
  • parahippocampal gyrus
  • sulci
  • gyri

Cite this

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abstract = "The density of diffuse, primitive and classic beta/A4 protein deposits was estimated in sulci and gyri in the frontal cortex and parahippocampal gyrus (PHG) in 8 cases of Alzheimer's disease. Total beta/A4 deposit density was similar in the frontal cortex and PHG but the ratio of primitive and classic deposits to the total was greater in the PHG compared with the frontal cortex. Total beta/A4 deposit density was greater in the depths of the sulci, but the proportions of the various beta/A4 subtypes were similar in sulci and gyri. Hence, increased density of primitive and classic deposits in the PHG could reflect enhanced conversion of diffuse to mature deposits whereas increased density of mature beta/A4 subtypes in sulci versus gyri may reflect increased beta/A4 deposition in the sulci.",
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Quantitative differences in beta/A4 protein subtypes in the parahippocampal gyrus and frontal cortex in Alzheimer's disease. / Armstrong, Richard A.

In: Dementia and Geriatric Cognitive Disorders, Vol. 5, No. 1, 1994, p. 1-5.

Research output: Contribution to journalArticle

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