Quantitative interpretation of diffusion-ordered NMR spectra: can we rationalize small molecule diffusion coefficients?

Robert Evans; Zhaoxia Deng; Alexandria K. Rogerson; Andy S. McLachlan; Jeff J. Richards; Mathias Nilsson; Gareth A. Morris

doi:10.1002/anie.201207403

Quantitative interpretation of diffusion-ordered NMR spectra: can we rationalize small molecule diffusion coefficients?

Robert Evans
, Zhaoxia Deng
, Alexandria K. Rogerson
, Andy S. McLachlan
, Jeff J. Richards
, Mathias Nilsson
, Gareth A. Morris

Chemical Engineering & Applied Chemistry

Københavns Universitet
University of Manchester
GlaxoSmithKline, Stevenage
Advanced Chemistry Development, Inc.

Research output: Contribution to journal › Article › peer-review

217 Citations (SciVal)

Abstract

Appealingly simple: A new method is described that allows the diffusion coefficient of a small molecule to be estimated given only the molecular weight and the viscosity of the solvent used. This method makes possible the quantitative interpretation of the diffusion domain of diffusion-ordered NMR spectra (see picture).

Original language	English
Pages (from-to)	3199-3202
Number of pages	4
Journal	Angewandte Chemie
Volume	52
Issue number	11
Early online date	31 Jan 2013
DOIs	https://doi.org/10.1002/anie.201207403
Publication status	Published - 11 Mar 2013

Keywords

analytical methods
diffusion
diffusion-ordered spectroscopy
molecular weight
NMR spectroscopy

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10.1002/anie.201207403

Cite this

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abstract = "Appealingly simple: A new method is described that allows the diffusion coefficient of a small molecule to be estimated given only the molecular weight and the viscosity of the solvent used. This method makes possible the quantitative interpretation of the diffusion domain of diffusion-ordered NMR spectra (see picture).",

keywords = "analytical methods, diffusion, diffusion-ordered spectroscopy, molecular weight, NMR spectroscopy",

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AU - Richards, Jeff J.

AU - Nilsson, Mathias

AU - Morris, Gareth A.

PY - 2013/3/11

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KW - analytical methods

KW - diffusion

KW - diffusion-ordered spectroscopy

KW - molecular weight

KW - NMR spectroscopy

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UR - http://onlinelibrary.wiley.com/doi/10.1002/anie.201207403/abstract

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Quantitative interpretation of diffusion-ordered NMR spectra: can we rationalize small molecule diffusion coefficients?

Abstract

Keywords

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