Questionnaire Design and Use to Assess Dry Eye Disease

Symptomology is critical to the diagnosis of dry eye disease and is what separates it from general ocular surface disease. As the screening element of the diagnosis of dry eye, standardization is essential and the two TFOS DEWS II accepted questionnaires are the Ocular Surface Disease Index (cut-off ≥13 out of 100) or the DEQ-5 (cut-off ≥6 out of 22). This chapter identified that none of the existing questionnaires meet current best practice for patient reported outcome design and none stand out for their sensitivity. Hence, the choice of questionnaire for monitoring treatment should be based on the respondent burden (related to the number of questions) and recall frequency (to fit with the follow-up schedule).