Real-time detection of DNA interactions with long-period fiber-grating-based biosensor

Xianfeng Chen; Lin Zhang; Kaiming Zhou; Edward Davies; Kate Sugden; Ian Bennion; Marcus D. Hughes; Anna V. Hine

doi:10.1364/OL.32.002541

Real-time detection of DNA interactions with long-period fiber-grating-based biosensor

Xianfeng Chen^*, Lin Zhang, Kaiming Zhou, Edward Davies, Kate Sugden, Ian Bennion, Marcus D. Hughes, Anna V. Hine

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Using an optical biosensor based on a dual-peak long-period fiber grating, we have demonstrated the detection of interactions between biomolecules in real time. Silanization of the grating surface was successfully realized for the covalent immobilization of probe DNA, which was subsequently hybridized with the complementary target DNA sequence. It is interesting to note that the DNA biosensor was reusable after being stripped off the hybridized target DNA from the grating surface, demonstrating a function of multiple usability. © 2007 Optical Society of America.

Original language	English
Pages (from-to)	2541-2543
Number of pages	3
Journal	Optics Letters
Volume	32
Issue number	17
DOIs	https://doi.org/10.1364/OL.32.002541
Publication status	Published - 20 Aug 2007

Bibliographical note

© 2007 Optical Society of America. This paper was published in Optics Letters and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-32-17-2541. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.

Keywords

biosensing techniques
DNA
equipment design
ebium
interferometry
lasers
light
models, theoretical
oscillometry
semiconductors
time factors
Ytterbium

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10.1364/OL.32.002541

Real-time detection of DNA interactions with longperiod fiber-grating-based biosensor
© 2007 Optical Society of America. This paper was published in Optics Letters and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-32-17-2541. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.
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Cite this

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title = "Real-time detection of DNA interactions with long-period fiber-grating-based biosensor",

abstract = "Using an optical biosensor based on a dual-peak long-period fiber grating, we have demonstrated the detection of interactions between biomolecules in real time. Silanization of the grating surface was successfully realized for the covalent immobilization of probe DNA, which was subsequently hybridized with the complementary target DNA sequence. It is interesting to note that the DNA biosensor was reusable after being stripped off the hybridized target DNA from the grating surface, demonstrating a function of multiple usability. {\textcopyright} 2007 Optical Society of America.",

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author = "Xianfeng Chen and Lin Zhang and Kaiming Zhou and Edward Davies and Kate Sugden and Ian Bennion and Hughes, {Marcus D.} and Hine, {Anna V.}",

note = "{\textcopyright} 2007 Optical Society of America. This paper was published in Optics Letters and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-32-17-2541. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.",

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AU - Zhang, Lin

AU - Zhou, Kaiming

AU - Davies, Edward

AU - Sugden, Kate

AU - Bennion, Ian

AU - Hughes, Marcus D.

AU - Hine, Anna V.

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AB - Using an optical biosensor based on a dual-peak long-period fiber grating, we have demonstrated the detection of interactions between biomolecules in real time. Silanization of the grating surface was successfully realized for the covalent immobilization of probe DNA, which was subsequently hybridized with the complementary target DNA sequence. It is interesting to note that the DNA biosensor was reusable after being stripped off the hybridized target DNA from the grating surface, demonstrating a function of multiple usability. © 2007 Optical Society of America.

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KW - DNA

KW - equipment design

KW - ebium

KW - interferometry

KW - lasers

KW - light

KW - models, theoretical

KW - oscillometry

KW - semiconductors

KW - time factors

KW - Ytterbium

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JO - Optics Letters

JF - Optics Letters

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ER -

Real-time detection of DNA interactions with long-period fiber-grating-based biosensor

Abstract

Bibliographical note

Keywords

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