Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers

Li Gan, Jing Wang, Min Jiang, Hannah Bartlett, Defang Ouyang, Frank Eperjesi, Jianping Liu, Gan Yong

Research output: Contribution to journalArticle

Abstract

Ocular barriers and the poor water solubility of drug candidates present a number of problems for the development of ocular drug delivery systems. Recently, the emergence of lipid-based nanocarriers has provided a viable means of enhancing the bioavailability of ophthalmic formulations. A number of these formulations have been found to be clinically active and several others are currently undergoing clinical trials. In this review, the advantages of lipid-based nanocarriers as non-invasive topical ocular drug delivery systems are presented. Many systems, including emulsions, liposomes, cubosomes, niosomes and other lipid-based nanocarriers, are reviewed.
LanguageEnglish
Pages290-297
Number of pages8
JournalDrug Discovery Today
Volume18
Issue number5-6
Early online date22 Oct 2012
DOIs
Publication statusPublished - Mar 2013

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Lipids
Drug Delivery Systems
Liposomes
Pharmaceutical Preparations
Emulsions
Solubility
Biological Availability
Clinical Trials
Water

Cite this

Gan, Li ; Wang, Jing ; Jiang, Min ; Bartlett, Hannah ; Ouyang, Defang ; Eperjesi, Frank ; Liu, Jianping ; Yong, Gan. / Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers. In: Drug Discovery Today. 2013 ; Vol. 18, No. 5-6. pp. 290-297.
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Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers. / Gan, Li; Wang, Jing; Jiang, Min; Bartlett, Hannah; Ouyang, Defang; Eperjesi, Frank; Liu, Jianping; Yong, Gan.

In: Drug Discovery Today, Vol. 18, No. 5-6, 03.2013, p. 290-297.

Research output: Contribution to journalArticle

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