Receptor activity modifying proteins and their potential as drug targets

Denise L. Wootten, John Simms, Debbie L. Hay, Arthur Christopoulos, Patrick M. Sexton

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The receptor activity modifying proteins (RAMPs) are a family of membrane proteins that interact with some G protein-coupled receptors (GPCRs) to regulate their function. RAMPs can alter GPCR pharmacology and can regulate their signaling as well as trafficking to and from the cell surface. GPCRs have been successfully exploited as drug targets for many years. RAMPs therefore provide a new avenue for drug development, offering opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. RAMPs could be directly targeted themselves or advantage could be taken of the unique RAMP/GPCR interfaces for generating more selective drugs.

Original languageEnglish
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier
Chapter3
Pages53-79
Number of pages27
EditionC
DOIs
Publication statusPublished - 1 Jan 2010

Publication series

NameProgress in Molecular Biology and Translational Science
NumberC
Volume91
ISSN (Print)1877-1173

Keywords

  • Adrenomedullin (AM)
  • Amylin (AMY)
  • Calcitonin (CT)
  • Calcitonin gene-related peptide (CGRP)
  • Calcitonin receptor (CTR)
  • Calcitonin receptor-like receptor (CLR)
  • Drug discovery
  • G protein-coupled receptor (GPCR)
  • Receptor activity modifying proteins (RAMPs)

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