Reduced transferrin binding in Down syndrome: a route to senile plaque formation and dementia

Paul S. Hodgkins, Vee Prasher, Gill Farrar, Richard A. Armstrong, Steven Sturman, John Corbett, John A. Blair

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma transferrin binding in Down syndrome and Alzheimer's disease is significantly reduced compared with age matched controls and it was thought this may help elucidate a pathological time sequence for the onset of dementia in Down syndrome. In Down syndrome, there was a reduction in gallium and aluminium transferrin binding both with age and the onset of dementia. Non-transferrin bound gallium species were identified as non-transportable phosphate or silicate. Thus, the route of entry of metals into the brain must be via a transferrin mediated complex only. A clear sequence of pathological events has been demonstrated in Down syndrome which shows the pathway to development of plaques and dementia and this is believed to have an immunological origin.
Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalNeuroReport
Volume5
Issue number1
Publication statusPublished - Oct 1993

Keywords

  • plasma transferrin binding
  • down syndrome
  • Alzheimer's disease
  • pathological time sequence
  • onset of dementia
  • dementia
  • senile plaque
  • transferrin

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