Reducing suffering in animal models and procedures involving seizures, convulsions and epilepsy

Sarah Wolfensohn, Penny Hawkins, Elliot Lilley, Daniel Anthony, Charles Chambers, Sarah Lane, Martin Lawton, Sally Robinson, Hanna-Marja Voipio, Gavin Woodhall

Research output: Contribution to journalArticle

Abstract

This report is based on discussions and submissions from an expert working group consisting of veterinarians, animal care staff and scientists with expert knowledge relevant to the field and aims to facilitate the implementation of the Three Rs (replacement, reduction and refinement) in the use of animal models or procedures involving seizures, convulsions and epilepsy. Each of these conditions will be considered, the specific welfare issues discussed, and practical measures to reduce animal use and suffering suggested. The emphasis is on refinement since this has the greatest potential for immediate implementation, and some general issues for refinement are summarised to help achieve this, with more detail provided on a range of specific refinements.
Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalJournal of Pharmacological and Toxicological Methods
Volume67
Issue number1
Early online date20 Sep 2012
DOIs
Publication statusPublished - Jan 2013

Keywords

  • animal welfare
  • refinement
  • three Rs
  • seizures
  • convulsions
  • epilepsy

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    Wolfensohn, S., Hawkins, P., Lilley, E., Anthony, D., Chambers, C., Lane, S., Lawton, M., Robinson, S., Voipio, H-M., & Woodhall, G. (2013). Reducing suffering in animal models and procedures involving seizures, convulsions and epilepsy. Journal of Pharmacological and Toxicological Methods, 67(1), 9-15. https://doi.org/10.1016/j.vascn.2012.09.001