Regulation of G protein-coupled receptors by palmitoylation and cholesterol

Alan D. Goddard, Anthony Watts*

*Corresponding author for this work

Research output: Contribution to journalLetter, comment/opinion or interviewpeer-review


Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors.See research article

Original languageEnglish
Article number27
Number of pages3
JournalBMC Biology
Publication statusPublished - 19 Mar 2012

Bibliographical note

© 2012 Goddard and Watts; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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