Regulation of G protein-coupled receptors by palmitoylation and cholesterol

Alan D. Goddard; Anthony Watts

doi:10.1186/1741-7007-10-27

Regulation of G protein-coupled receptors by palmitoylation and cholesterol

Alan D. Goddard
, Anthony Watts^*

^*Corresponding author for this work

College of Health and Life Sciences

University of Oxford

Research output: Contribution to journal › Letter, comment/opinion or interview › peer-review

57 Citations (Scopus)

79 Downloads (Pure)

Abstract

Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors.See research article http://www.biomedcentral.com/1471-2121/13/6.

Original language	English
Article number	27
Number of pages	3
Journal	BMC Biology
Volume	10
DOIs	https://doi.org/10.1186/1741-7007-10-27
Publication status	Published - 19 Mar 2012

Bibliographical note

© 2012 Goddard and Watts; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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10.1186/1741-7007-10-27Licence: CC BY 3.0

Regulation of G protein-coupled receptors by palmitoylation and cholesterol
© 2012 Goddard and Watts; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 437 KBLicence: CC BY 3.0

Cite this

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AB - Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors.See research article http://www.biomedcentral.com/1471-2121/13/6.

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Regulation of G protein-coupled receptors by palmitoylation and cholesterol

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