Reprint of: Proteomics in cardiovascular diseases::  Unveiling sex and gender differences in the era of precision medicine

Roberta Baetta; Marta Pontremoli; Alma Martinez Fernandez; Corinne M Spickett; Cristina Banfi

doi:10.1016/j.jprot.2018.03.017

Reprint of: Proteomics in cardiovascular diseases: Unveiling sex and gender differences in the era of precision medicine

Roberta Baetta, Marta Pontremoli, Alma Martinez Fernandez, Corinne M Spickett, Cristina Banfi

Research output: Contribution to journal › Article › peer-review

Abstract

Cardiovascular diseases (CVDs) represent the most important cause of mortality in women and in men. Contrary to the long-standing notion that the effects of the major risk factors on CVD outcomes are the same in both sexes, recent evidence recognizes new, potentially independent, sex/gender-related risk factors for CVDs, and sex/gender-differences in the clinical presentation of CVDs have been demonstrated. Furthermore, some therapeutic options may not be equally effective and safe in men and women. In this context, proteomics offers an extremely useful and versatile analytical platform for biomedical researches that expand from the screening of early diagnostic and prognostic biomarkers to the investigation of the molecular mechanisms underlying CDVs. In this review, we summarized the current applications of proteomics in the cardiovascular field, with emphasis on sex and gender-related differences in CVDs.

Original language	English
Pages (from-to)	57-72
Journal	Journal of Proteomics
Volume	178
Early online date	3 Apr 2018
DOIs	https://doi.org/10.1016/j.jprot.2018.03.017
Publication status	Published - 30 Apr 2018

Bibliographical note

Keywords

Sex differences
Gender
Cardiovascular disease
Risk factors
Oxidative stress
Proteomics

Access to Document

10.1016/j.jprot.2018.03.017

Reprint of: Proteomics in cardiovascular diseases: unveiling sex and gender differences
© 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 1.13 MBLicence: CC BY-NC-ND 3.0

Cite this

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title = "Reprint of: Proteomics in cardiovascular diseases:: Unveiling sex and gender differences in the era of precision medicine",

abstract = "Cardiovascular diseases (CVDs) represent the most important cause of mortality in women and in men. Contrary to the long-standing notion that the effects of the major risk factors on CVD outcomes are the same in both sexes, recent evidence recognizes new, potentially independent, sex/gender-related risk factors for CVDs, and sex/gender-differences in the clinical presentation of CVDs have been demonstrated. Furthermore, some therapeutic options may not be equally effective and safe in men and women. In this context, proteomics offers an extremely useful and versatile analytical platform for biomedical researches that expand from the screening of early diagnostic and prognostic biomarkers to the investigation of the molecular mechanisms underlying CDVs. In this review, we summarized the current applications of proteomics in the cardiovascular field, with emphasis on sex and gender-related differences in CVDs.",

keywords = "Sex differences, Gender, Cardiovascular disease, Risk factors, Oxidative stress, Proteomics",

author = "Roberta Baetta and Marta Pontremoli and Fernandez, {Alma Martinez} and Spickett, {Corinne M} and Cristina Banfi",

note = "{\textcopyright} 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ ",

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AU - Spickett, Corinne M

AU - Banfi, Cristina

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AB - Cardiovascular diseases (CVDs) represent the most important cause of mortality in women and in men. Contrary to the long-standing notion that the effects of the major risk factors on CVD outcomes are the same in both sexes, recent evidence recognizes new, potentially independent, sex/gender-related risk factors for CVDs, and sex/gender-differences in the clinical presentation of CVDs have been demonstrated. Furthermore, some therapeutic options may not be equally effective and safe in men and women. In this context, proteomics offers an extremely useful and versatile analytical platform for biomedical researches that expand from the screening of early diagnostic and prognostic biomarkers to the investigation of the molecular mechanisms underlying CDVs. In this review, we summarized the current applications of proteomics in the cardiovascular field, with emphasis on sex and gender-related differences in CVDs.

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