Reprint of: Proteomics in cardiovascular diseases:: Unveiling sex and gender differences in the era of precision medicine

Roberta Baetta, Marta Pontremoli, Alma Martinez Fernandez, Corinne M Spickett, Cristina Banfi

Research output: Contribution to journalArticle

Abstract

Cardiovascular diseases (CVDs) represent the most important cause of mortality in women and in men. Contrary to the long-standing notion that the effects of the major risk factors on CVD outcomes are the same in both sexes, recent evidence recognizes new, potentially independent, sex/gender-related risk factors for CVDs, and sex/gender-differences in the clinical presentation of CVDs have been demonstrated. Furthermore, some therapeutic options may not be equally effective and safe in men and women. In this context, proteomics offers an extremely useful and versatile analytical platform for biomedical researches that expand from the screening of early diagnostic and prognostic biomarkers to the investigation of the molecular mechanisms underlying CDVs. In this review, we summarized the current applications of proteomics in the cardiovascular field, with emphasis on sex and gender-related differences in CVDs.
LanguageEnglish
Pages57-72
JournalJournal of Proteomics
Volume178
Early online date3 Apr 2018
DOIs
Publication statusPublished - 30 Apr 2018

Fingerprint

Precision Medicine
Sex Characteristics
Proteomics
Medicine
Cardiovascular Diseases
Biomarkers
Biomedical Research
Screening
Mortality

Bibliographical note

© 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

  • Sex differences
  • Gender
  • Cardiovascular disease
  • Risk factors
  • Oxidative stress
  • Proteomics

Cite this

Baetta, Roberta ; Pontremoli, Marta ; Fernandez, Alma Martinez ; Spickett, Corinne M ; Banfi, Cristina. / Reprint of: Proteomics in cardiovascular diseases: Unveiling sex and gender differences in the era of precision medicine. In: Journal of Proteomics. 2018 ; Vol. 178. pp. 57-72.
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Reprint of: Proteomics in cardiovascular diseases: Unveiling sex and gender differences in the era of precision medicine. / Baetta, Roberta; Pontremoli, Marta; Fernandez, Alma Martinez; Spickett, Corinne M; Banfi, Cristina.

In: Journal of Proteomics, Vol. 178, 30.04.2018, p. 57-72.

Research output: Contribution to journalArticle

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