Reproducibility and repeatability of the OcuSense TearLab™ osmometer

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Some studies report that increased tear osmolarity is a reliable indicator of dry eye syndrome (DES). The OcuSense TearLab™ osmometer requires less than a 100-nl sample of tears and provides an instant quantitative result. Our aim was to clinically evaluate this instrument in terms of its reproducibility and repeatability. METHODS: Twenty-nine participants who ranged in age from 19 to 49 years (mean?±?SD: 23.3?±?5.5 years) were recruited. Osmolarity readings were collected by two operators, in two sessions separated by 1 or 2 weeks in order to assess test reproducibility and repeatability. RESULTS: The coefficient of reproducibility was 39 mOsms/l; the coefficient of repeatability was 33 mOsms/l. CONCLUSIONS: Our mean coefficient of variation over four readings for 29 subjects is 2.9%, which compares well with that reported by the manufacturer. Our results inform practitioners about the level of change over time that can be considered clinically relevant for healthy subjects. This value is 33mOsms/l; any change smaller than this could be attributed to measurement noise.
LanguageEnglish
Pages1201-1205
Number of pages5
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume250
Issue number8
Early online date21 Feb 2012
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Tears
Osmolar Concentration
Reading
Dry Eye Syndromes
Noise
Healthy Volunteers

Bibliographical note

The original publication is available at www.springerlink.com

Keywords

  • dry eye
  • osmolarity
  • osmometer
  • TearLab
  • tears

Cite this

@article{4232bc63edc54a27b534bbad7381008d,
title = "Reproducibility and repeatability of the OcuSense TearLab™ osmometer",
abstract = "BACKGROUND: Some studies report that increased tear osmolarity is a reliable indicator of dry eye syndrome (DES). The OcuSense TearLab™ osmometer requires less than a 100-nl sample of tears and provides an instant quantitative result. Our aim was to clinically evaluate this instrument in terms of its reproducibility and repeatability. METHODS: Twenty-nine participants who ranged in age from 19 to 49 years (mean?±?SD: 23.3?±?5.5 years) were recruited. Osmolarity readings were collected by two operators, in two sessions separated by 1 or 2 weeks in order to assess test reproducibility and repeatability. RESULTS: The coefficient of reproducibility was 39 mOsms/l; the coefficient of repeatability was 33 mOsms/l. CONCLUSIONS: Our mean coefficient of variation over four readings for 29 subjects is 2.9{\%}, which compares well with that reported by the manufacturer. Our results inform practitioners about the level of change over time that can be considered clinically relevant for healthy subjects. This value is 33mOsms/l; any change smaller than this could be attributed to measurement noise.",
keywords = "dry eye, osmolarity, osmometer, TearLab, tears",
author = "Frank Eperjesi and Maana Aujla and {Bartlett Eperjesi}, Hannah",
note = "The original publication is available at www.springerlink.com",
year = "2012",
month = "8",
doi = "10.1007/s00417-012-1961-4",
language = "English",
volume = "250",
pages = "1201--1205",
journal = "Graefe's Archive for Clinical and Experimental Ophthalmology",
issn = "0721-832X",
publisher = "Springer",
number = "8",

}

Reproducibility and repeatability of the OcuSense TearLab™ osmometer. / Eperjesi, Frank; Aujla, Maana; Bartlett Eperjesi, Hannah.

In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 250, No. 8, 08.2012, p. 1201-1205.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Reproducibility and repeatability of the OcuSense TearLab™ osmometer

AU - Eperjesi, Frank

AU - Aujla, Maana

AU - Bartlett Eperjesi, Hannah

N1 - The original publication is available at www.springerlink.com

PY - 2012/8

Y1 - 2012/8

N2 - BACKGROUND: Some studies report that increased tear osmolarity is a reliable indicator of dry eye syndrome (DES). The OcuSense TearLab™ osmometer requires less than a 100-nl sample of tears and provides an instant quantitative result. Our aim was to clinically evaluate this instrument in terms of its reproducibility and repeatability. METHODS: Twenty-nine participants who ranged in age from 19 to 49 years (mean?±?SD: 23.3?±?5.5 years) were recruited. Osmolarity readings were collected by two operators, in two sessions separated by 1 or 2 weeks in order to assess test reproducibility and repeatability. RESULTS: The coefficient of reproducibility was 39 mOsms/l; the coefficient of repeatability was 33 mOsms/l. CONCLUSIONS: Our mean coefficient of variation over four readings for 29 subjects is 2.9%, which compares well with that reported by the manufacturer. Our results inform practitioners about the level of change over time that can be considered clinically relevant for healthy subjects. This value is 33mOsms/l; any change smaller than this could be attributed to measurement noise.

AB - BACKGROUND: Some studies report that increased tear osmolarity is a reliable indicator of dry eye syndrome (DES). The OcuSense TearLab™ osmometer requires less than a 100-nl sample of tears and provides an instant quantitative result. Our aim was to clinically evaluate this instrument in terms of its reproducibility and repeatability. METHODS: Twenty-nine participants who ranged in age from 19 to 49 years (mean?±?SD: 23.3?±?5.5 years) were recruited. Osmolarity readings were collected by two operators, in two sessions separated by 1 or 2 weeks in order to assess test reproducibility and repeatability. RESULTS: The coefficient of reproducibility was 39 mOsms/l; the coefficient of repeatability was 33 mOsms/l. CONCLUSIONS: Our mean coefficient of variation over four readings for 29 subjects is 2.9%, which compares well with that reported by the manufacturer. Our results inform practitioners about the level of change over time that can be considered clinically relevant for healthy subjects. This value is 33mOsms/l; any change smaller than this could be attributed to measurement noise.

KW - dry eye

KW - osmolarity

KW - osmometer

KW - TearLab

KW - tears

UR - http://www.scopus.com/inward/record.url?scp=84866424715&partnerID=8YFLogxK

U2 - 10.1007/s00417-012-1961-4

DO - 10.1007/s00417-012-1961-4

M3 - Article

VL - 250

SP - 1201

EP - 1205

JO - Graefe's Archive for Clinical and Experimental Ophthalmology

T2 - Graefe's Archive for Clinical and Experimental Ophthalmology

JF - Graefe's Archive for Clinical and Experimental Ophthalmology

SN - 0721-832X

IS - 8

ER -