Research update: alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease

H. Rheinallt Parri, Caterina M. Hernandez, Kelly T. Dineley

Research output: Contribution to journalArticle

Abstract

Aberrant amyloid-ß peptide (Aß) accumulation along with altered expression and function of nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's disease (AD). Since the discovery that Aß is bound to a7 nAChRs under many experimental settings, including post-mortem AD brain, much effort has been expended to understand the implications of this interaction in the disease milieu. This research update will review the current literature on the a7 nAChR-Aß interaction in vitro and in vivo, the functional consequences of this interaction from sub-cellular to cognitive levels, and discuss the implications these relationships might have for AD therapies.
Original languageEnglish
Pages (from-to)931-942
Number of pages12
JournalBiochemical Pharmacology
Volume82
Issue number8
Early online date7 Jul 2011
DOIs
Publication statusPublished - 15 Oct 2011

Keywords

  • allosteric regulation
  • Alzheimer disease
  • amyloid beta-peptides
  • animals binding sites
  • cognition
  • humans
  • learning
  • memory
  • protein binding
  • nicotinic receptors
  • signal transduction
  • synaptic transmission

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