Abstract
Aberrant amyloid-ß peptide (Aß) accumulation along with altered expression and function of nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's disease (AD). Since the discovery that Aß is bound to a7 nAChRs under many experimental settings, including post-mortem AD brain, much effort has been expended to understand the implications of this interaction in the disease milieu. This research update will review the current literature on the a7 nAChR-Aß interaction in vitro and in vivo, the functional consequences of this interaction from sub-cellular to cognitive levels, and discuss the implications these relationships might have for AD therapies.
Original language | English |
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Pages (from-to) | 931-942 |
Number of pages | 12 |
Journal | Biochemical Pharmacology |
Volume | 82 |
Issue number | 8 |
Early online date | 7 Jul 2011 |
DOIs | |
Publication status | Published - 15 Oct 2011 |
Keywords
- allosteric regulation
- Alzheimer disease
- amyloid beta-peptides
- animals binding sites
- cognition
- humans
- learning
- memory
- protein binding
- nicotinic receptors
- signal transduction
- synaptic transmission