In the modern work environment self-control demands have been identified as a unique job stressor. In the present chapter we review research on self-control demands and present empirical evidence on interindvidual and intraindividual resources, which buffer the adverse impact of self-control demands on employees’ well-being. Our overview shows that different forms of self-control demands as stable work-related characteristics (impulse control, resisting distractions, overcoming inner resistances) contribute to significant portions of unique variance in the prediction of various measures of job strain and impaired well-being. Moreover, the relation of self-control demands to well-being is moderated by various personal and organizational resources such as self-controlcapacity, physical fitness, and job control. Moreover, recent research has demonstrated that self-control demands may also fluctauate from day to day and that high day-specific self-control demands also impair employees’ well-being. Finally, affective commitment, psychological detachment and flow experiences are presented as further resources, which buffer the adverse day-specific effects of self-control demands at work.