Retinoblastoma and the new genetics

Richard A. Armstrong, S.N. Smith

Research output: Contribution to specialist publication or newspaperArticle


Wardop first described retinoblastoma in 1809. It is the most common intraocular tumour of childhood and the most common tumour of the retina. It was originally thought to be a glioma arising from glial cells of the retina. However, in 1926 it was recognised as a tumour of undifferentiated photoreceptor cells. This article describes the basic clinical and pathological aspects of retinoblastoma, the advances in molecular genetics which have led to the discovery of the gene responsible, and the defects which have been discovered in the retinoblastoma gene.
Original languageEnglish
Number of pages5
Specialist publicationOptometry Today
Publication statusPublished - 12 Mar 1999


  • retinoblastoma
  • intraocular tumour
  • childhood
  • tumour
  • retina
  • undifferentiated photoreceptor cells
  • molecular genetics
  • gene
  • retinoblastoma gene


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