Reversing cachexia

Michael J. Tisdale*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skeletal and cardiac muscle and increased life span by blocking ActRIIB with a decoy receptor.

Original languageEnglish
Pages (from-to)511-512
Number of pages2
Issue number4
Publication statusPublished - 20 Aug 2010


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