Reversing cachexia

Michael J. Tisdale

doi:10.1016/j.cell.2010.08.004

Reversing cachexia

Michael J. Tisdale^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skeletal and cardiac muscle and increased life span by blocking ActRIIB with a decoy receptor.

Original language	English
Pages (from-to)	511-512
Number of pages	2
Journal	Cell
Volume	142
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2010.08.004
Publication status	Published - 20 Aug 2010

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10.1016/j.cell.2010.08.004

https://www.sciencedirect.com/science/article/pii/S0092867410008998?via%3DihubLicence: Other

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title = "Reversing cachexia",

abstract = "Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skeletal and cardiac muscle and increased life span by blocking ActRIIB with a decoy receptor.",

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Reversing cachexia

Abstract

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