Rho-kinase as a therapeutic target in vascular diseases: striking nitric oxide signaling

Gopi Krishna Kolluru; Syamantak Majumder; Suvro Chatterjee

doi:10.1016/j.niox.2014.09.002

Rho-kinase as a therapeutic target in vascular diseases: striking nitric oxide signaling

Gopi Krishna Kolluru, Syamantak Majumder, Suvro Chatterjee

Aston Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Rho GTPases are a globular, monomeric group of small signaling G-protein molecules. Rho-associated protein kinase/Rho-kinase (ROCK) is a downstream effector protein of the Rho GTPase. Rho-kinases are the potential therapeutic targets in the treatment of cardiovascular diseases. Here, we have primarily discussed the intriguing roles of ROCK in cardiovascular health in relation to nitric oxide signaling. Further, we highlighted the biphasic effects of Y-27632, a ROCK inhibitor under shear stress, which acts as an agonist of nitric oxide production in endothelial cells. The biphasic effects of this inhibitor raised the question of safety of the drug usage in treating cardiovascular diseases.

Original language	English
Pages (from-to)	45-54
Number of pages	10
Journal	Nitric Oxide
Volume	43
Early online date	6 Sept 2014
DOIs	https://doi.org/10.1016/j.niox.2014.09.002
Publication status	Published - 1 Dec 2014

Keywords

amides
drug delivery systems
rho-associated kinases
nitric oxide
protein kinase inhibitors
pyridines
signal transduction
vascular diseases

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10.1016/j.niox.2014.09.002

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title = "Rho-kinase as a therapeutic target in vascular diseases: striking nitric oxide signaling",

abstract = "Rho GTPases are a globular, monomeric group of small signaling G-protein molecules. Rho-associated protein kinase/Rho-kinase (ROCK) is a downstream effector protein of the Rho GTPase. Rho-kinases are the potential therapeutic targets in the treatment of cardiovascular diseases. Here, we have primarily discussed the intriguing roles of ROCK in cardiovascular health in relation to nitric oxide signaling. Further, we highlighted the biphasic effects of Y-27632, a ROCK inhibitor under shear stress, which acts as an agonist of nitric oxide production in endothelial cells. The biphasic effects of this inhibitor raised the question of safety of the drug usage in treating cardiovascular diseases.",

keywords = "amides, drug delivery systems, rho-associated kinases, nitric oxide, protein kinase inhibitors, pyridines, signal transduction, vascular diseases",

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AU - Kolluru, Gopi Krishna

AU - Majumder, Syamantak

AU - Chatterjee, Suvro

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Rho GTPases are a globular, monomeric group of small signaling G-protein molecules. Rho-associated protein kinase/Rho-kinase (ROCK) is a downstream effector protein of the Rho GTPase. Rho-kinases are the potential therapeutic targets in the treatment of cardiovascular diseases. Here, we have primarily discussed the intriguing roles of ROCK in cardiovascular health in relation to nitric oxide signaling. Further, we highlighted the biphasic effects of Y-27632, a ROCK inhibitor under shear stress, which acts as an agonist of nitric oxide production in endothelial cells. The biphasic effects of this inhibitor raised the question of safety of the drug usage in treating cardiovascular diseases.

AB - Rho GTPases are a globular, monomeric group of small signaling G-protein molecules. Rho-associated protein kinase/Rho-kinase (ROCK) is a downstream effector protein of the Rho GTPase. Rho-kinases are the potential therapeutic targets in the treatment of cardiovascular diseases. Here, we have primarily discussed the intriguing roles of ROCK in cardiovascular health in relation to nitric oxide signaling. Further, we highlighted the biphasic effects of Y-27632, a ROCK inhibitor under shear stress, which acts as an agonist of nitric oxide production in endothelial cells. The biphasic effects of this inhibitor raised the question of safety of the drug usage in treating cardiovascular diseases.

KW - amides

KW - drug delivery systems

KW - rho-associated kinases

KW - nitric oxide

KW - protein kinase inhibitors

KW - pyridines

KW - signal transduction

KW - vascular diseases

U2 - 10.1016/j.niox.2014.09.002

DO - 10.1016/j.niox.2014.09.002

M3 - Article

C2 - 25196952

SN - 1089-8603

VL - 43

SP - 45

EP - 54

JO - Nitric Oxide

JF - Nitric Oxide

ER -

Rho-kinase as a therapeutic target in vascular diseases: striking nitric oxide signaling

Abstract

Keywords

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