Rho-kinase as a therapeutic target in vascular diseases: striking nitric oxide signaling

Gopi Krishna Kolluru, Syamantak Majumder, Suvro Chatterjee

Research output: Contribution to journalArticle

Abstract

Rho GTPases are a globular, monomeric group of small signaling G-protein molecules. Rho-associated protein kinase/Rho-kinase (ROCK) is a downstream effector protein of the Rho GTPase. Rho-kinases are the potential therapeutic targets in the treatment of cardiovascular diseases. Here, we have primarily discussed the intriguing roles of ROCK in cardiovascular health in relation to nitric oxide signaling. Further, we highlighted the biphasic effects of Y-27632, a ROCK inhibitor under shear stress, which acts as an agonist of nitric oxide production in endothelial cells. The biphasic effects of this inhibitor raised the question of safety of the drug usage in treating cardiovascular diseases.

Original languageEnglish
Pages (from-to)45-54
Number of pages10
JournalNitric Oxide
Volume43
Early online date6 Sep 2014
DOIs
Publication statusPublished - 1 Dec 2014

Keywords

  • amides
  • drug delivery systems
  • rho-associated kinases
  • nitric oxide
  • protein kinase inhibitors
  • pyridines
  • signal transduction
  • vascular diseases

Fingerprint Dive into the research topics of 'Rho-kinase as a therapeutic target in vascular diseases: striking nitric oxide signaling'. Together they form a unique fingerprint.

  • Cite this