Rho-kinase as a therapeutic target in vascular diseases: striking nitric oxide signaling

Gopi Krishna Kolluru, Syamantak Majumder, Suvro Chatterjee

Research output: Contribution to journalArticle

Abstract

Rho GTPases are a globular, monomeric group of small signaling G-protein molecules. Rho-associated protein kinase/Rho-kinase (ROCK) is a downstream effector protein of the Rho GTPase. Rho-kinases are the potential therapeutic targets in the treatment of cardiovascular diseases. Here, we have primarily discussed the intriguing roles of ROCK in cardiovascular health in relation to nitric oxide signaling. Further, we highlighted the biphasic effects of Y-27632, a ROCK inhibitor under shear stress, which acts as an agonist of nitric oxide production in endothelial cells. The biphasic effects of this inhibitor raised the question of safety of the drug usage in treating cardiovascular diseases.

Original languageEnglish
Pages (from-to)45-54
Number of pages10
JournalNitric Oxide
Volume43
Early online date6 Sep 2014
DOIs
Publication statusPublished - 1 Dec 2014

Fingerprint

rho-Associated Kinases
rho GTP-Binding Proteins
Vascular Diseases
Nitric Oxide
Endothelial cells
Cardiovascular Diseases
GTP-Binding Proteins
Protein Kinases
Shear stress
Monomeric GTP-Binding Proteins
Health
Molecules
Therapeutics
Endothelial Cells
Pharmaceutical Preparations
Safety
Proteins
Y 27632

Keywords

  • amides
  • drug delivery systems
  • rho-associated kinases
  • nitric oxide
  • protein kinase inhibitors
  • pyridines
  • signal transduction
  • vascular diseases

Cite this

Kolluru, Gopi Krishna ; Majumder, Syamantak ; Chatterjee, Suvro. / Rho-kinase as a therapeutic target in vascular diseases : striking nitric oxide signaling. In: Nitric Oxide. 2014 ; Vol. 43. pp. 45-54.
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Rho-kinase as a therapeutic target in vascular diseases : striking nitric oxide signaling. / Kolluru, Gopi Krishna; Majumder, Syamantak; Chatterjee, Suvro.

In: Nitric Oxide, Vol. 43, 01.12.2014, p. 45-54.

Research output: Contribution to journalArticle

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T1 - Rho-kinase as a therapeutic target in vascular diseases

T2 - striking nitric oxide signaling

AU - Kolluru, Gopi Krishna

AU - Majumder, Syamantak

AU - Chatterjee, Suvro

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

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AB - Rho GTPases are a globular, monomeric group of small signaling G-protein molecules. Rho-associated protein kinase/Rho-kinase (ROCK) is a downstream effector protein of the Rho GTPase. Rho-kinases are the potential therapeutic targets in the treatment of cardiovascular diseases. Here, we have primarily discussed the intriguing roles of ROCK in cardiovascular health in relation to nitric oxide signaling. Further, we highlighted the biphasic effects of Y-27632, a ROCK inhibitor under shear stress, which acts as an agonist of nitric oxide production in endothelial cells. The biphasic effects of this inhibitor raised the question of safety of the drug usage in treating cardiovascular diseases.

KW - amides

KW - drug delivery systems

KW - rho-associated kinases

KW - nitric oxide

KW - protein kinase inhibitors

KW - pyridines

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