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RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells

  • Rehna Krishnan
  • , Mariah Lapierre
  • , Brandon Gautreau
  • , Kevin C.J. Nixon
  • , Samah El Ghamrasni
  • , Parasvi S. Patel
  • , Jun Hao
  • , V. Talya Yerlici
  • , Kiran Kumar Naidu Guturi
  • , Jonathan St-Germain
  • , Francesca Mateo
  • , Amine Saad
  • , Arash Algouneh
  • , Rebecca Earnshaw
  • , Duan Shili
  • , Alma Seitova
  • , Joshua Miller
  • , Negin Khosraviani
  • , Adam Penn
  • , Brandon Ho
  • Otto Sanchez, M. Prakash Hande, Jean Yves Masson, Grant W. Brown, Moulay Alaoui-Jamali, John J. Reynolds, Cheryl Arrowsmith, Brian Raught, Miguel A. Pujana, Karim Mekhail, Grant S. Stewart, Anne Hakem*, Razqallah Hakem*
*Corresponding author for this work
  • Princess Margaret Cancer Centre
  • University of Toronto Faculty of Medicine
  • McGill University
  • University of Toronto
  • UOIT
  • Yong Loo Lin School of Medicine
  • Laval University Cancer Research Center
  • University of Birmingham, College of Medical and Dental Sciences

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Biochemistry, Genetics and Molecular Biology