RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells

Rehna Krishnan, Mariah Lapierre, Brandon Gautreau, Kevin C.J. Nixon, Samah El Ghamrasni, Parasvi S. Patel, Jun Hao, V. Talya Yerlici, Kiran Kumar Naidu Guturi, Jonathan St-Germain, Francesca Mateo, Amine Saad, Arash Algouneh, Rebecca Earnshaw, Duan Shili, Alma Seitova, Joshua Miller, Negin Khosraviani, Adam Penn, Brandon HoOtto Sanchez, M. Prakash Hande, Jean Yves Masson, Grant W. Brown, Moulay Alaoui-Jamali, John J. Reynolds, Cheryl Arrowsmith, Brian Raught, Miguel A. Pujana, Karim Mekhail, Grant S. Stewart, Anne Hakem*, Razqallah Hakem*

*Corresponding author for this work

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Biochemistry, Genetics and Molecular Biology