Role of waveform signal parameters in the classification of children as relatively slow and fast myopia progressors

Kin Wan, James Stuart Wolffsohn, Pauline Cho

Research output: Contribution to journalArticlepeer-review

Abstract

Clinical Relevance: Identification of the baseline characteristics for
children undergoing orthokeratology with relatively fast myopia
progression can allow a more accurate determination of the risk/benefit
ratio.
Background: This study aimed to investigate if baseline corneal
biomechanics can classify relatively slow and fast myopia progression in
children.
Methods: Children aged six to 12 years with low myopia (0.50 to 4.00 D)
and astigmatism (less than or equal to 1.25 D), were recruited.
Participants were randomised to be fitted with ortho-k lenses of different
compression factors [0.75 D (OK-CCF) n=29 or 1.75 D (OK-ICF) n=33].
Relatively fast progressors were defined as participants who had axial
elongation (AE) of 0.34 mm or above per two years. A binomial logistic
regression analysis and a classification and regression tree (CART) model
were used in the data analysis. The corneal biomechanics were
measured with a bidirectional applanation device. Axial length was
measured by a masked examiner.
Results: As there were no significant between-group differences in
baseline data (all p > 0.05), data were combined for analysis. The mean
± SD AE for relatively slow (n=27) and fast (n=35) progressors were
0.18 ± 0.14 mm and 0.64 ± 0.23 mm per two years, respectively.
p2area1 was significantly higher in relatively fast progressors (p =
0.018). The binomial logistic regression and CART analysis showed
baseline age and p2area1 could differentiate slow and fast progressors
over two years.
Conclusions: Corneal biomechanics could be a potential predictor of AE in
ortho-k lens wearing children. A further investigation with a larger
sample size is warranted to confirm the applicability of the finding.
Original languageEnglish
JournalClinical and Experimental Optometry
Early online date16 Feb 2023
DOIs
Publication statusE-pub ahead of print - 16 Feb 2023

Bibliographical note

Funding: The work was supported by the The Hong Kong Polytechnic University [Research Residency Scheme]; Menicon Co. Ltd., Japan [Collaborative Research Agreement (ZG3Z)].
This is an Accepted Manuscript version of the following article, accepted for publication in Clinical and Experimental Optometry. Kin Wan, James Stuart Wolffsohn & Pauline Cho (2023) Role of waveform signal parameters in the classification of children as relatively slow and fast myopia progressors, Clinical and Experimental Optometry, DOI: 10.1080/08164622.2023.2177098. It is deposited under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

  • Corneal biomechanics
  • myopia
  • orthokeratology

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