Saffron (Crocus sativus L.) in ocular diseases: a narrative review of the existing evidence from clinical studies

Research output: Contribution to journalReview article

Abstract

Saffron (Crocus sativus L.) and its main constituents, i.e., crocin and crocetin, are natural carotenoid compounds, which have been reported to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuroprotective effects. An increasing number of experimental, animal, and human studies have investigated the effects and mechanistic pathways of these compounds in order to assess their potential therapeutic use in ocular diseases (e.g., in age related macular degeneration, glaucoma, and diabetic maculopathy). This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of ocular disease, as well as an overview of the proposed underlying mechanisms mediating these effects.

Original languageEnglish
Article number649
JournalNutrients
Volume11
Issue number3
DOIs
Publication statusPublished - 18 Mar 2019

Fingerprint

eye diseases
Crocus sativus
saffron
Eye Diseases
clinical trials
neuroprotective effect
glaucoma
laboratory animals
carotenoids
Macular Degeneration
Neuroprotective Agents
Therapeutic Uses
Carotenoids
Glaucoma
therapeutics
Anti-Inflammatory Agents
Clinical Studies
macular degeneration

Bibliographical note

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Keywords

  • AMD
  • Anti-inflammatory
  • Anti-oxidant
  • Crocetin
  • Crocin
  • Crocus Sativus L
  • Diabetes
  • Glaucoma
  • Saffron
  • Supplements

Cite this

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title = "Saffron (Crocus sativus L.) in ocular diseases: a narrative review of the existing evidence from clinical studies",
abstract = "Saffron (Crocus sativus L.) and its main constituents, i.e., crocin and crocetin, are natural carotenoid compounds, which have been reported to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuroprotective effects. An increasing number of experimental, animal, and human studies have investigated the effects and mechanistic pathways of these compounds in order to assess their potential therapeutic use in ocular diseases (e.g., in age related macular degeneration, glaucoma, and diabetic maculopathy). This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of ocular disease, as well as an overview of the proposed underlying mechanisms mediating these effects.",
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author = "Rebekka Heitmar and Brown, {James E} and Ioannis Kyrou",
note = "{\circledC} 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).",
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AU - Kyrou, Ioannis

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AB - Saffron (Crocus sativus L.) and its main constituents, i.e., crocin and crocetin, are natural carotenoid compounds, which have been reported to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuroprotective effects. An increasing number of experimental, animal, and human studies have investigated the effects and mechanistic pathways of these compounds in order to assess their potential therapeutic use in ocular diseases (e.g., in age related macular degeneration, glaucoma, and diabetic maculopathy). This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of ocular disease, as well as an overview of the proposed underlying mechanisms mediating these effects.

KW - AMD

KW - Anti-inflammatory

KW - Anti-oxidant

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KW - Crocin

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KW - Diabetes

KW - Glaucoma

KW - Saffron

KW - Supplements

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