SARS-CoV-2 IgG Seroprevalence among Blood Donors as a Monitor of the COVID-19 Epidemic, Brazil

Daniel G. Chaves*, Ricardo H.C. Takahashi, Felipe Campelo, Maria Clara F.S. Malta, Isabelle R. Oliveira, Edel F. Barbosa-Stancioli, Maisa A. Ribeiro, Marina L. Martins

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


During epidemics, data from different sources can provide information on varying aspects of the epidemic process. Serology-based epidemiologic surveys could be used to compose a consistent epidemic scenario. We assessed the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG in serum samples collected from 7,837 blood donors in 7 cities of Brazil during March-December 2020. Based on our results, we propose a modification in a compartmental model that uses reported number of SARS-CoV-2 cases and serology results from blood donors as inputs and delivers estimates of hidden variables, such as daily values of SARS-CoV-2 transmission rates and cumulative incidence rate of reported and unreported SARS-CoV-2 cases. We concluded that the information about cumulative incidence of a disease in a city's population can be obtained by testing serum samples collected from blood donors. Our proposed method also can be extended to surveillance of other infectious diseases.

Original languageEnglish
Pages (from-to)734-742
Number of pages9
JournalEmerging Infectious Diseases
Issue number4
Early online date18 Feb 2022
Publication statusPublished - Apr 2022

Bibliographical note

Chaves DG, Takahashi RHC, Campelo F, da Silva-Malta MCF, de Oliveira IR, Barbosa-Stancioli EF, et al. SARS-CoV-2 IgG seroprevalence among blood donors as a monitor of the COVID-19 epidemic, Brazil. Emerg Infect Dis. 2022 Apr [date cited].


  • Antibodies, Viral
  • Blood Donors
  • Brazil/epidemiology
  • COVID-19/epidemiology
  • Epidemics
  • Humans
  • Immunoglobulin G
  • SARS-CoV-2
  • Seroepidemiologic Studies


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