Sensitivity adjustable biosensor based on graphene oxide coated excessively tilted fiber grating

Yuezhen Sun; Xiaoxia Guo; Yarien Moreno; Qizhen Sun; Zhijun Yan; Lin Zhang

doi:10.1016/j.snb.2021.130832

Sensitivity adjustable biosensor based on graphene oxide coated excessively tilted fiber grating

Yuezhen Sun, Xiaoxia Guo^*, Yarien Moreno, Qizhen Sun, Zhijun Yan, Lin Zhang

^*Corresponding author for this work

College of Engineering and Physical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Biosensors play a significant role in biomedical, clinical and disease diagnosis areas. Here, we proposed Langmuir adsorption model to explain sensing mechanism of biosensor based on excessively tilted fiber grating (Ex-TFG) functionalized with graphene oxide (GO). Due to GO containing plenty of six-membered rings and oxygen-containing groups, the biomolecules can be easily adsorbed through π-π interaction and hydrogen bond. The whole interaction process obeys the Langmuir adsorption model in which there always an equilibrium during detecting process, inducing the sensor with adjustable bio-sensitivity and detection range. Three biosensors based on Ex-TFG coated with three different amount of GO were investigated for hemoglobin (Hb) detection experiment, showing pronounced bio-interaction induced resonance shifts. The experiment results indicate that GO coating could enhance the surface biological activity of Ex-TFG, making the Ex-TFG sensitive to the Hb biomolecule solutions. The three GO coated Ex-TFG sensors have the bio-sensitivity of 3.83 nm/(mg/ml), 4.33 nm/(mg/ml), and 8.21 nm/(mg/ml), and the detection range of 0.8 mg/ml, 0.6 mg/ml and 0.4 mg/ml, respectively, which are in good agreement with the prediction from the Langmuir adsorption model. By controlling the amount of the bio-functionalized materials, the bio-sensitivity and detection range of the Ex-TFG based biosensors can be easily adjusted.

Original language	English
Article number	130832
Journal	Sensors and Actuators, B: Chemical
Volume	351
Early online date	12 Oct 2021
DOIs	https://doi.org/10.1016/j.snb.2021.130832
Publication status	Published - 15 Jan 2022

Bibliographical note

© 2021, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/.

Funding: This work was supported in part by National Natural Science Foundation of China (No. 62075071) and in part by the National Science Fund for Excellent Young Scholars (No. 61922033).

Keywords

Dynamic detection range
Graphene oxide
Langmuir adsorption
Selectable sensitivity

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10.1016/j.snb.2021.130832

Sensitivity Tunable Biosensor Based on Graphene
© 2021, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/.
Accepted author manuscript, 1.63 MBLicence: CC BY-NC-ND 3.0

Cite this

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title = "Sensitivity adjustable biosensor based on graphene oxide coated excessively tilted fiber grating",

abstract = "Biosensors play a significant role in biomedical, clinical and disease diagnosis areas. Here, we proposed Langmuir adsorption model to explain sensing mechanism of biosensor based on excessively tilted fiber grating (Ex-TFG) functionalized with graphene oxide (GO). Due to GO containing plenty of six-membered rings and oxygen-containing groups, the biomolecules can be easily adsorbed through π-π interaction and hydrogen bond. The whole interaction process obeys the Langmuir adsorption model in which there always an equilibrium during detecting process, inducing the sensor with adjustable bio-sensitivity and detection range. Three biosensors based on Ex-TFG coated with three different amount of GO were investigated for hemoglobin (Hb) detection experiment, showing pronounced bio-interaction induced resonance shifts. The experiment results indicate that GO coating could enhance the surface biological activity of Ex-TFG, making the Ex-TFG sensitive to the Hb biomolecule solutions. The three GO coated Ex-TFG sensors have the bio-sensitivity of 3.83 nm/(mg/ml), 4.33 nm/(mg/ml), and 8.21 nm/(mg/ml), and the detection range of 0.8 mg/ml, 0.6 mg/ml and 0.4 mg/ml, respectively, which are in good agreement with the prediction from the Langmuir adsorption model. By controlling the amount of the bio-functionalized materials, the bio-sensitivity and detection range of the Ex-TFG based biosensors can be easily adjusted.",

keywords = "Dynamic detection range, Graphene oxide, Langmuir adsorption, Selectable sensitivity",

author = "Yuezhen Sun and Xiaoxia Guo and Yarien Moreno and Qizhen Sun and Zhijun Yan and Lin Zhang",

note = "{\textcopyright} 2021, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/. Funding: This work was supported in part by National Natural Science Foundation of China (No. 62075071) and in part by the National Science Fund for Excellent Young Scholars (No. 61922033).",

year = "2022",

month = jan,

day = "15",

doi = "10.1016/j.snb.2021.130832",

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T1 - Sensitivity adjustable biosensor based on graphene oxide coated excessively tilted fiber grating

AU - Sun, Yuezhen

AU - Guo, Xiaoxia

AU - Moreno, Yarien

AU - Sun, Qizhen

AU - Yan, Zhijun

AU - Zhang, Lin

N1 - © 2021, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/. Funding: This work was supported in part by National Natural Science Foundation of China (No. 62075071) and in part by the National Science Fund for Excellent Young Scholars (No. 61922033).

PY - 2022/1/15

Y1 - 2022/1/15

N2 - Biosensors play a significant role in biomedical, clinical and disease diagnosis areas. Here, we proposed Langmuir adsorption model to explain sensing mechanism of biosensor based on excessively tilted fiber grating (Ex-TFG) functionalized with graphene oxide (GO). Due to GO containing plenty of six-membered rings and oxygen-containing groups, the biomolecules can be easily adsorbed through π-π interaction and hydrogen bond. The whole interaction process obeys the Langmuir adsorption model in which there always an equilibrium during detecting process, inducing the sensor with adjustable bio-sensitivity and detection range. Three biosensors based on Ex-TFG coated with three different amount of GO were investigated for hemoglobin (Hb) detection experiment, showing pronounced bio-interaction induced resonance shifts. The experiment results indicate that GO coating could enhance the surface biological activity of Ex-TFG, making the Ex-TFG sensitive to the Hb biomolecule solutions. The three GO coated Ex-TFG sensors have the bio-sensitivity of 3.83 nm/(mg/ml), 4.33 nm/(mg/ml), and 8.21 nm/(mg/ml), and the detection range of 0.8 mg/ml, 0.6 mg/ml and 0.4 mg/ml, respectively, which are in good agreement with the prediction from the Langmuir adsorption model. By controlling the amount of the bio-functionalized materials, the bio-sensitivity and detection range of the Ex-TFG based biosensors can be easily adjusted.

AB - Biosensors play a significant role in biomedical, clinical and disease diagnosis areas. Here, we proposed Langmuir adsorption model to explain sensing mechanism of biosensor based on excessively tilted fiber grating (Ex-TFG) functionalized with graphene oxide (GO). Due to GO containing plenty of six-membered rings and oxygen-containing groups, the biomolecules can be easily adsorbed through π-π interaction and hydrogen bond. The whole interaction process obeys the Langmuir adsorption model in which there always an equilibrium during detecting process, inducing the sensor with adjustable bio-sensitivity and detection range. Three biosensors based on Ex-TFG coated with three different amount of GO were investigated for hemoglobin (Hb) detection experiment, showing pronounced bio-interaction induced resonance shifts. The experiment results indicate that GO coating could enhance the surface biological activity of Ex-TFG, making the Ex-TFG sensitive to the Hb biomolecule solutions. The three GO coated Ex-TFG sensors have the bio-sensitivity of 3.83 nm/(mg/ml), 4.33 nm/(mg/ml), and 8.21 nm/(mg/ml), and the detection range of 0.8 mg/ml, 0.6 mg/ml and 0.4 mg/ml, respectively, which are in good agreement with the prediction from the Langmuir adsorption model. By controlling the amount of the bio-functionalized materials, the bio-sensitivity and detection range of the Ex-TFG based biosensors can be easily adjusted.

KW - Dynamic detection range

KW - Graphene oxide

KW - Langmuir adsorption

KW - Selectable sensitivity

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U2 - 10.1016/j.snb.2021.130832

DO - 10.1016/j.snb.2021.130832

M3 - Article

SN - 0925-4005

VL - 351

JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

M1 - 130832

ER -

Sensitivity adjustable biosensor based on graphene oxide coated excessively tilted fiber grating

Abstract

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Keywords

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