Sensor and software use for the glycaemic management of insulin-treated type 1 and type 2 diabetes patients

Ramzi A. Ajjan*, Kamal Abougila, Srikanth Bellary, Andrew Collier, Bernd Franke, Edward B. Jude, Gerry Rayman, Anthony Robinson, Baldev M. Singh

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Lowering glucose levels, while avoiding hypoglycaemia, can be challenging in insulin-treated patients with diabetes. We evaluated the role of ambulatory glucose profile in optimising glycaemic control in this population. Insulin-treated patients with type 1 and type 2 diabetes were recruited into a prospective, multicentre, 100-day study and randomised to control (n = 28) or intervention (n = 59) groups. The intervention group used ambulatory glucose profile, generated by continuous glucose monitoring, to assess daily glucose levels, whereas the controls relied on capillary glucose testing. Patients were reviewed at days 30 and 45 by the health care professional to adjust insulin therapy. Comparing first and last 2 weeks of the study, ambulatory glucose profile-monitored type 2 diabetes patients (n = 28) showed increased time in euglycaemia (mean ± standard deviation) by 1.4 ± 3.5 h/day (p = 0.0427) associated with reduction in HbA1c from 77 ± 15 to 67 ± 13 mmol/mol (p = 0.0002) without increased hypoglycaemia. Type 1 diabetes patients (n = 25) showed reduction in hypoglycaemia from 1.4 ± 1.7 to 0.8 ± 0.8 h/day (p = 0.0472) associated with a marginal HbA1c decrease from 75 ± 10 to 72 ± 8 mmol/mol (p = 0.0508). Largely similar findings were observed comparing intervention and control groups at end of study. In conclusion, ambulatory glucose profile helps glycaemic management in insulin-treated diabetes patients by increasing time spent in euglycaemia and decreasing HbA1c in type 2 diabetes patients, while reducing hypoglycaemia in type 1 diabetes patients.

Original languageEnglish
Pages (from-to)211-219
Number of pages9
JournalDiabetes and Vascular Disease Research
Volume13
Issue number3
Early online date21 Mar 2016
DOIs
Publication statusPublished - 1 May 2016

Bibliographical note

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Keywords

  • ambulatory glucose profile
  • glycaemia self-monitoring of blood glucose
  • type 1 diabetes
  • type 2 diabetes

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    Ajjan, R. A., Abougila, K., Bellary, S., Collier, A., Franke, B., Jude, E. B., Rayman, G., Robinson, A., & Singh, B. M. (2016). Sensor and software use for the glycaemic management of insulin-treated type 1 and type 2 diabetes patients. Diabetes and Vascular Disease Research, 13(3), 211-219. https://doi.org/10.1177/1479164115624680