Serum α-tocopherol has a nonlinear inverse association with periodontitis among US adults

Geng Zong, Ann Scott, Helen Griffiths, Peter Zock, Thomas Dietrich, Rachel Newson

Research output: Contribution to journalMeeting abstract

Abstract

Previous experimental models suggest that vitamin E may ameliorate periodontitis. However, epidemiologic studies show inconsistent evidence in supporting this plausible association. We aimed to investigate the association between serum α-tocopherol (αT) and γ-tocopherol (γT) and periodontitis in a large cross-sectional US population. This study included 4708 participants in the 1999–2001 NHANES. Serum tocopherols were measured by HPLC and values were adjusted by total cholesterol (TC). Periodontal status was assessed by mean clinical attachment loss (CAL) and probing pocket depth (PPD). Total periodontitis (TPD) was defined as the sum of mild, moderate, and severe periodontitis. All measurements were performed by NHANES. Means ± SDs of serum αT:TC ratio from low to high quartiles were 4.0 ± 0.4, 4.8 ± 0.2, 5.7 ± 0.4, and 9.1 ± 2.7 μmol/mmol. In multivariate regression models, αT:TC quartiles were inversely associated with mean CAL (P-trend = 0.06), mean PPD (P-trend < 0.001), and TPD (P-trend < 0.001) overall. Adjusted mean differences (95% CIs) between the first and fourth quartile of αT:TC were 0.12 mm (0.03, 0.20; P-difference = 0.005) for mean CAL and 0.12 mm (0.06, 0.17; P < 0.001) for mean PPD, whereas corresponding OR for TPD was 1.65 (95% CI: 1.26, 2.16; P-difference = 0.001). In a dose-response analysis, a clear inverse association between αT:TC and mean CAL, mean PPD, and TPD was observed among participants with relatively low αT:TC. No differences were seen in participants with higher αT:TC ratios. Participants with γT:TC ratio in the interquartile range showed a significantly lower mean PPD than those in the highest quartile. A nonlinear inverse association was observed between serum αT and severity of periodontitis, which was restricted to adults with normal but relatively low αT status. These findings warrant further confirmation in longitudinal or intervention settings.
Original languageEnglish
Article numberPP67
Pages (from-to)S41-S42
Number of pages2
JournalFree Radical Biology and Medicine
Volume86
Issue numberSuppl.1
Early online date28 Aug 2015
DOIs
Publication statusPublished - 1 Sep 2015
EventSFRR-E/SNFS Meeting Stuttgart 2015 - University of Hohenheim, Stuttgart, Germany
Duration: 1 Sep 2015 → …

Fingerprint

Tocopherols
Periodontitis
Cholesterol
Serum
Nutrition Surveys
Vitamin E
Epidemiologic Studies
Theoretical Models
High Pressure Liquid Chromatography

Bibliographical note

SFRR-E/SNFS Conference Abstracts, Stuttgart 2015

Cite this

Zong, Geng ; Scott, Ann ; Griffiths, Helen ; Zock, Peter ; Dietrich, Thomas ; Newson, Rachel. / Serum α-tocopherol has a nonlinear inverse association with periodontitis among US adults. In: Free Radical Biology and Medicine. 2015 ; Vol. 86, No. Suppl.1. pp. S41-S42.
@article{b77eb08aec1e471fb99954796a83841c,
title = "Serum α-tocopherol has a nonlinear inverse association with periodontitis among US adults",
abstract = "Previous experimental models suggest that vitamin E may ameliorate periodontitis. However, epidemiologic studies show inconsistent evidence in supporting this plausible association. We aimed to investigate the association between serum α-tocopherol (αT) and γ-tocopherol (γT) and periodontitis in a large cross-sectional US population. This study included 4708 participants in the 1999–2001 NHANES. Serum tocopherols were measured by HPLC and values were adjusted by total cholesterol (TC). Periodontal status was assessed by mean clinical attachment loss (CAL) and probing pocket depth (PPD). Total periodontitis (TPD) was defined as the sum of mild, moderate, and severe periodontitis. All measurements were performed by NHANES. Means ± SDs of serum αT:TC ratio from low to high quartiles were 4.0 ± 0.4, 4.8 ± 0.2, 5.7 ± 0.4, and 9.1 ± 2.7 μmol/mmol. In multivariate regression models, αT:TC quartiles were inversely associated with mean CAL (P-trend = 0.06), mean PPD (P-trend < 0.001), and TPD (P-trend < 0.001) overall. Adjusted mean differences (95{\%} CIs) between the first and fourth quartile of αT:TC were 0.12 mm (0.03, 0.20; P-difference = 0.005) for mean CAL and 0.12 mm (0.06, 0.17; P < 0.001) for mean PPD, whereas corresponding OR for TPD was 1.65 (95{\%} CI: 1.26, 2.16; P-difference = 0.001). In a dose-response analysis, a clear inverse association between αT:TC and mean CAL, mean PPD, and TPD was observed among participants with relatively low αT:TC. No differences were seen in participants with higher αT:TC ratios. Participants with γT:TC ratio in the interquartile range showed a significantly lower mean PPD than those in the highest quartile. A nonlinear inverse association was observed between serum αT and severity of periodontitis, which was restricted to adults with normal but relatively low αT status. These findings warrant further confirmation in longitudinal or intervention settings.",
author = "Geng Zong and Ann Scott and Helen Griffiths and Peter Zock and Thomas Dietrich and Rachel Newson",
note = "SFRR-E/SNFS Conference Abstracts, Stuttgart 2015",
year = "2015",
month = "9",
day = "1",
doi = "10.1016/j.freeradbiomed.2015.07.142",
language = "English",
volume = "86",
pages = "S41--S42",
journal = "Free Radical Biology and Medicine",
issn = "0891-5849",
publisher = "Elsevier",
number = "Suppl.1",

}

Zong, G, Scott, A, Griffiths, H, Zock, P, Dietrich, T & Newson, R 2015, 'Serum α-tocopherol has a nonlinear inverse association with periodontitis among US adults', Free Radical Biology and Medicine, vol. 86, no. Suppl.1, PP67, pp. S41-S42. https://doi.org/10.1016/j.freeradbiomed.2015.07.142

Serum α-tocopherol has a nonlinear inverse association with periodontitis among US adults. / Zong, Geng; Scott, Ann; Griffiths, Helen; Zock, Peter; Dietrich, Thomas; Newson, Rachel.

In: Free Radical Biology and Medicine, Vol. 86, No. Suppl.1, PP67, 01.09.2015, p. S41-S42.

Research output: Contribution to journalMeeting abstract

TY - JOUR

T1 - Serum α-tocopherol has a nonlinear inverse association with periodontitis among US adults

AU - Zong, Geng

AU - Scott, Ann

AU - Griffiths, Helen

AU - Zock, Peter

AU - Dietrich, Thomas

AU - Newson, Rachel

N1 - SFRR-E/SNFS Conference Abstracts, Stuttgart 2015

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Previous experimental models suggest that vitamin E may ameliorate periodontitis. However, epidemiologic studies show inconsistent evidence in supporting this plausible association. We aimed to investigate the association between serum α-tocopherol (αT) and γ-tocopherol (γT) and periodontitis in a large cross-sectional US population. This study included 4708 participants in the 1999–2001 NHANES. Serum tocopherols were measured by HPLC and values were adjusted by total cholesterol (TC). Periodontal status was assessed by mean clinical attachment loss (CAL) and probing pocket depth (PPD). Total periodontitis (TPD) was defined as the sum of mild, moderate, and severe periodontitis. All measurements were performed by NHANES. Means ± SDs of serum αT:TC ratio from low to high quartiles were 4.0 ± 0.4, 4.8 ± 0.2, 5.7 ± 0.4, and 9.1 ± 2.7 μmol/mmol. In multivariate regression models, αT:TC quartiles were inversely associated with mean CAL (P-trend = 0.06), mean PPD (P-trend < 0.001), and TPD (P-trend < 0.001) overall. Adjusted mean differences (95% CIs) between the first and fourth quartile of αT:TC were 0.12 mm (0.03, 0.20; P-difference = 0.005) for mean CAL and 0.12 mm (0.06, 0.17; P < 0.001) for mean PPD, whereas corresponding OR for TPD was 1.65 (95% CI: 1.26, 2.16; P-difference = 0.001). In a dose-response analysis, a clear inverse association between αT:TC and mean CAL, mean PPD, and TPD was observed among participants with relatively low αT:TC. No differences were seen in participants with higher αT:TC ratios. Participants with γT:TC ratio in the interquartile range showed a significantly lower mean PPD than those in the highest quartile. A nonlinear inverse association was observed between serum αT and severity of periodontitis, which was restricted to adults with normal but relatively low αT status. These findings warrant further confirmation in longitudinal or intervention settings.

AB - Previous experimental models suggest that vitamin E may ameliorate periodontitis. However, epidemiologic studies show inconsistent evidence in supporting this plausible association. We aimed to investigate the association between serum α-tocopherol (αT) and γ-tocopherol (γT) and periodontitis in a large cross-sectional US population. This study included 4708 participants in the 1999–2001 NHANES. Serum tocopherols were measured by HPLC and values were adjusted by total cholesterol (TC). Periodontal status was assessed by mean clinical attachment loss (CAL) and probing pocket depth (PPD). Total periodontitis (TPD) was defined as the sum of mild, moderate, and severe periodontitis. All measurements were performed by NHANES. Means ± SDs of serum αT:TC ratio from low to high quartiles were 4.0 ± 0.4, 4.8 ± 0.2, 5.7 ± 0.4, and 9.1 ± 2.7 μmol/mmol. In multivariate regression models, αT:TC quartiles were inversely associated with mean CAL (P-trend = 0.06), mean PPD (P-trend < 0.001), and TPD (P-trend < 0.001) overall. Adjusted mean differences (95% CIs) between the first and fourth quartile of αT:TC were 0.12 mm (0.03, 0.20; P-difference = 0.005) for mean CAL and 0.12 mm (0.06, 0.17; P < 0.001) for mean PPD, whereas corresponding OR for TPD was 1.65 (95% CI: 1.26, 2.16; P-difference = 0.001). In a dose-response analysis, a clear inverse association between αT:TC and mean CAL, mean PPD, and TPD was observed among participants with relatively low αT:TC. No differences were seen in participants with higher αT:TC ratios. Participants with γT:TC ratio in the interquartile range showed a significantly lower mean PPD than those in the highest quartile. A nonlinear inverse association was observed between serum αT and severity of periodontitis, which was restricted to adults with normal but relatively low αT status. These findings warrant further confirmation in longitudinal or intervention settings.

U2 - 10.1016/j.freeradbiomed.2015.07.142

DO - 10.1016/j.freeradbiomed.2015.07.142

M3 - Meeting abstract

VL - 86

SP - S41-S42

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

SN - 0891-5849

IS - Suppl.1

M1 - PP67

ER -