The unconjugated pterin neopterin is secreted by macrophages activated by interferon-gamma and hence, the level of neopterin in serum may be used as a marker of a cellular immune response in a patient. Serum neopterin levels were measured by high performance liquid chromatography (HPLC) in 28 Parkinson's disease (PD) patients and 28 age and sex matched controls. The level of serum neopterin was significantly elevated in PD compared with controls suggesting immune activation in these patients. The level of neopterin was negatively correlated with the level of binding of gallium to transferrin (Tf) but unrelated to the level of iron binding. Hence, in PD, it is possible that a cellular immune response may be important in the pathogenesis of the disease. One effect of the cellular immune response may be a reduction in the binding of metals other than iron to Tf and this could also be a factor in PD.
|Publication status||Published - 1994|
|Event||Brain Research Association Conference - Southampton (UK)|
Duration: 11 Apr 1994 → 14 Apr 1994
|Conference||Brain Research Association Conference|
|Period||11/04/94 → 14/04/94|
Bibliographical noteAbstract appearing in Brain Res Assoc Abstr 11:P48.
- unconjugated pterin neopterin
- cellular immune response
- Parkinson's disease
Winsper, S. J., Armstrong, R. A., Pall, H., Fuchs, D., & Blair, J. A. (1994). Serum neopterin levels and gallium transferrin binding in Parkinson's disease. Poster session presented at Brain Research Association Conference, Southampton (UK), .