Serum neopterin levels and gallium transferrin binding in Parkinson's disease

S.J. Winsper, Richard A. Armstrong, H. Pall, D. Fuchs, J.A. Blair

Research output: Contribution to conferencePoster

Abstract

The unconjugated pterin neopterin is secreted by macrophages activated by interferon-gamma and hence, the level of neopterin in serum may be used as a marker of a cellular immune response in a patient. Serum neopterin levels were measured by high performance liquid chromatography (HPLC) in 28 Parkinson's disease (PD) patients and 28 age and sex matched controls. The level of serum neopterin was significantly elevated in PD compared with controls suggesting immune activation in these patients. The level of neopterin was negatively correlated with the level of binding of gallium to transferrin (Tf) but unrelated to the level of iron binding. Hence, in PD, it is possible that a cellular immune response may be important in the pathogenesis of the disease. One effect of the cellular immune response may be a reduction in the binding of metals other than iron to Tf and this could also be a factor in PD.
Original languageEnglish
Publication statusPublished - 1994
EventBrain Research Association Conference - Southampton (UK)
Duration: 11 Apr 199414 Apr 1994

Conference

ConferenceBrain Research Association Conference
CitySouthampton (UK)
Period11/04/9414/04/94

Fingerprint

Neopterin
Gallium
Transferrin
Parkinson Disease
Cellular Immunity
Serum
Iron
Pterins
Interferon-gamma
Metals
Macrophages
High Pressure Liquid Chromatography

Bibliographical note

Abstract appearing in Brain Res Assoc Abstr 11:P48.

Keywords

  • unconjugated pterin neopterin
  • macrophages
  • interferon-gamma
  • cellular immune response
  • Parkinson's disease

Cite this

Winsper, S. J., Armstrong, R. A., Pall, H., Fuchs, D., & Blair, J. A. (1994). Serum neopterin levels and gallium transferrin binding in Parkinson's disease. Poster session presented at Brain Research Association Conference, Southampton (UK), .
Winsper, S.J. ; Armstrong, Richard A. ; Pall, H. ; Fuchs, D. ; Blair, J.A. / Serum neopterin levels and gallium transferrin binding in Parkinson's disease. Poster session presented at Brain Research Association Conference, Southampton (UK), .
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abstract = "The unconjugated pterin neopterin is secreted by macrophages activated by interferon-gamma and hence, the level of neopterin in serum may be used as a marker of a cellular immune response in a patient. Serum neopterin levels were measured by high performance liquid chromatography (HPLC) in 28 Parkinson's disease (PD) patients and 28 age and sex matched controls. The level of serum neopterin was significantly elevated in PD compared with controls suggesting immune activation in these patients. The level of neopterin was negatively correlated with the level of binding of gallium to transferrin (Tf) but unrelated to the level of iron binding. Hence, in PD, it is possible that a cellular immune response may be important in the pathogenesis of the disease. One effect of the cellular immune response may be a reduction in the binding of metals other than iron to Tf and this could also be a factor in PD.",
keywords = "unconjugated pterin neopterin, macrophages, interferon-gamma, cellular immune response, Parkinson's disease",
author = "S.J. Winsper and Armstrong, {Richard A.} and H. Pall and D. Fuchs and J.A. Blair",
note = "Abstract appearing in Brain Res Assoc Abstr 11:P48.; Brain Research Association Conference ; Conference date: 11-04-1994 Through 14-04-1994",
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Winsper, SJ, Armstrong, RA, Pall, H, Fuchs, D & Blair, JA 1994, 'Serum neopterin levels and gallium transferrin binding in Parkinson's disease' Brain Research Association Conference, Southampton (UK), 11/04/94 - 14/04/94, .

Serum neopterin levels and gallium transferrin binding in Parkinson's disease. / Winsper, S.J.; Armstrong, Richard A.; Pall, H.; Fuchs, D.; Blair, J.A.

1994. Poster session presented at Brain Research Association Conference, Southampton (UK), .

Research output: Contribution to conferencePoster

TY - CONF

T1 - Serum neopterin levels and gallium transferrin binding in Parkinson's disease

AU - Winsper, S.J.

AU - Armstrong, Richard A.

AU - Pall, H.

AU - Fuchs, D.

AU - Blair, J.A.

N1 - Abstract appearing in Brain Res Assoc Abstr 11:P48.

PY - 1994

Y1 - 1994

N2 - The unconjugated pterin neopterin is secreted by macrophages activated by interferon-gamma and hence, the level of neopterin in serum may be used as a marker of a cellular immune response in a patient. Serum neopterin levels were measured by high performance liquid chromatography (HPLC) in 28 Parkinson's disease (PD) patients and 28 age and sex matched controls. The level of serum neopterin was significantly elevated in PD compared with controls suggesting immune activation in these patients. The level of neopterin was negatively correlated with the level of binding of gallium to transferrin (Tf) but unrelated to the level of iron binding. Hence, in PD, it is possible that a cellular immune response may be important in the pathogenesis of the disease. One effect of the cellular immune response may be a reduction in the binding of metals other than iron to Tf and this could also be a factor in PD.

AB - The unconjugated pterin neopterin is secreted by macrophages activated by interferon-gamma and hence, the level of neopterin in serum may be used as a marker of a cellular immune response in a patient. Serum neopterin levels were measured by high performance liquid chromatography (HPLC) in 28 Parkinson's disease (PD) patients and 28 age and sex matched controls. The level of serum neopterin was significantly elevated in PD compared with controls suggesting immune activation in these patients. The level of neopterin was negatively correlated with the level of binding of gallium to transferrin (Tf) but unrelated to the level of iron binding. Hence, in PD, it is possible that a cellular immune response may be important in the pathogenesis of the disease. One effect of the cellular immune response may be a reduction in the binding of metals other than iron to Tf and this could also be a factor in PD.

KW - unconjugated pterin neopterin

KW - macrophages

KW - interferon-gamma

KW - cellular immune response

KW - Parkinson's disease

M3 - Poster

ER -

Winsper SJ, Armstrong RA, Pall H, Fuchs D, Blair JA. Serum neopterin levels and gallium transferrin binding in Parkinson's disease. 1994. Poster session presented at Brain Research Association Conference, Southampton (UK), .