Shape-dependent interaction of gold nanoparticles with cultured cells at laser exposure

O. Bibikova, P. Singh, A. Popov, G. Akchurin, A. Skaptsov, I. Skovorodkin, V. Khanadeev, D. Mikhalevich, M. Kinnunen, G. Akchurin, V. Bogatyrev, N. Khlebtsov, S. J. Vainio, I. Meglinski, V. Tuchin

Research output: Contribution to journalArticlepeer-review


Laser optoporation of cells by local heating of plasmonic gold nanoparticles (GNPs) was proven as a favorable delivery method of molecules into cells. The optoporation efficiency depends on the laser beam intensity and GNP properties. Here, we evaluate the membrane optoporation in vitro in terms of fluorescent dye permeability under treatment of a multi-pulsed nanosecond 1064 nm laser with a sharply-focused beam. Anisotropic GNPs, such as nanorods and nanostars, were fabricated to achieve the optimal GNP-cell interaction. Nanostars demonstrated highest optoporation efficacy with more than 80% of permeabilized cells within the illuminated area. By contrast to common laser techniques, the laser beam scanning method results in cell optoporation within a controllable programmed in advance irradiated area.

Original languageEnglish
Article number055901
JournalLaser Physics Letters
Issue number5
Publication statusPublished - 20 May 2017


  • cell permeability
  • HeLa cells
  • laser beam scanning
  • nanosecond laser
  • optoporation
  • plasmon-resonant gold nanoparticles


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