Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective

Dragos V. Nica; George A. Draghici; Florina-maria Andrica; Sofia Popescu; Dorina E. Coricovac; Cristina A. Dehelean; Iosif I. Gergen; Leda Kovatsi; Michael D. Coleman; Aristidis Tsatsakis

doi:10.1016/j.etap.2018.10.005

Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective

Dragos V. Nica, George A. Draghici, Florina-maria Andrica, Sofia Popescu, Dorina E. Coricovac, Cristina A. Dehelean, Iosif I. Gergen, Leda Kovatsi, Michael D. Coleman, Aristidis Tsatsakis

Research output: Contribution to journal › Article › peer-review

Abstract

The available information on the interplay between low-dose cadmium intake and copper, manganese, and iron homeostasis in invertebrates is limited. We have currently studied the accumulation of these trace metals in the hepatopancreas of adult snails, Cantareus aspersus, following 14 and 28 days of exposure to low doses of dietary cadmium, up to 1 mg/kg dw (dry weight). The cadmium dose, but not the duration of exposure, had a significant effect on hepatopancreas copper deposition, the values being significantly elevated compared to controls. A significant peak in manganese levels at 14 days was found in snails administered the lowest cadmium dose. These increases occurred even in the absence of cadmium increase in the hepatopancreas. Our data suggest that low dose cadmium feeding can produce a transient disturbance in hepatopancreas copper and manganese homeostasis. Such responses may serve as early biomarkers of physiological changes occurring during the initial stages of cadmium intoxication.

Original language	English
Journal	Environmental Toxicology and Pharmacology
Early online date	28 Oct 2018
DOIs	https://doi.org/10.1016/j.etap.2018.10.005
Publication status	E-pub ahead of print - 28 Oct 2018

Bibliographical note

Keywords

cadmium
copper
manganese
iron
dietary exposure
land snails

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10.1016/j.etap.2018.10.005

Short-term effects of very low dose cadmium feeding
© 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 489 KBLicence: CC BY-NC-ND

https://linkinghub.elsevier.com/retrieve/pii/S1382668918305453

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Nica, Dragos V. ; Draghici, George A. ; Andrica, Florina-maria ; Popescu, Sofia ; Coricovac, Dorina E. ; Dehelean, Cristina A. ; Gergen, Iosif I. ; Kovatsi, Leda ; Coleman, Michael D. ; Tsatsakis, Aristidis. / Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective. In: Environmental Toxicology and Pharmacology. 2018.

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title = "Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective",

abstract = "The available information on the interplay between low-dose cadmium intake and copper, manganese, and iron homeostasis in invertebrates is limited. We have currently studied the accumulation of these trace metals in the hepatopancreas of adult snails, Cantareus aspersus, following 14 and 28 days of exposure to low doses of dietary cadmium, up to 1 mg/kg dw (dry weight). The cadmium dose, but not the duration of exposure, had a significant effect on hepatopancreas copper deposition, the values being significantly elevated compared to controls. A significant peak in manganese levels at 14 days was found in snails administered the lowest cadmium dose. These increases occurred even in the absence of cadmium increase in the hepatopancreas. Our data suggest that low dose cadmium feeding can produce a transient disturbance in hepatopancreas copper and manganese homeostasis. Such responses may serve as early biomarkers of physiological changes occurring during the initial stages of cadmium intoxication.",

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author = "Nica, {Dragos V.} and Draghici, {George A.} and Florina-maria Andrica and Sofia Popescu and Coricovac, {Dorina E.} and Dehelean, {Cristina A.} and Gergen, {Iosif I.} and Leda Kovatsi and Coleman, {Michael D.} and Aristidis Tsatsakis",

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Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective. / Nica, Dragos V.; Draghici, George A.; Andrica, Florina-maria; Popescu, Sofia; Coricovac, Dorina E.; Dehelean, Cristina A.; Gergen, Iosif I.; Kovatsi, Leda; Coleman, Michael D.; Tsatsakis, Aristidis.

In: Environmental Toxicology and Pharmacology, 28.10.2018.

Research output: Contribution to journal › Article › peer-review

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T1 - Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective

AU - Nica, Dragos V.

AU - Draghici, George A.

AU - Andrica, Florina-maria

AU - Popescu, Sofia

AU - Coricovac, Dorina E.

AU - Dehelean, Cristina A.

AU - Gergen, Iosif I.

AU - Kovatsi, Leda

AU - Coleman, Michael D.

AU - Tsatsakis, Aristidis

PY - 2018/10/28

Y1 - 2018/10/28

N2 - The available information on the interplay between low-dose cadmium intake and copper, manganese, and iron homeostasis in invertebrates is limited. We have currently studied the accumulation of these trace metals in the hepatopancreas of adult snails, Cantareus aspersus, following 14 and 28 days of exposure to low doses of dietary cadmium, up to 1 mg/kg dw (dry weight). The cadmium dose, but not the duration of exposure, had a significant effect on hepatopancreas copper deposition, the values being significantly elevated compared to controls. A significant peak in manganese levels at 14 days was found in snails administered the lowest cadmium dose. These increases occurred even in the absence of cadmium increase in the hepatopancreas. Our data suggest that low dose cadmium feeding can produce a transient disturbance in hepatopancreas copper and manganese homeostasis. Such responses may serve as early biomarkers of physiological changes occurring during the initial stages of cadmium intoxication.

AB - The available information on the interplay between low-dose cadmium intake and copper, manganese, and iron homeostasis in invertebrates is limited. We have currently studied the accumulation of these trace metals in the hepatopancreas of adult snails, Cantareus aspersus, following 14 and 28 days of exposure to low doses of dietary cadmium, up to 1 mg/kg dw (dry weight). The cadmium dose, but not the duration of exposure, had a significant effect on hepatopancreas copper deposition, the values being significantly elevated compared to controls. A significant peak in manganese levels at 14 days was found in snails administered the lowest cadmium dose. These increases occurred even in the absence of cadmium increase in the hepatopancreas. Our data suggest that low dose cadmium feeding can produce a transient disturbance in hepatopancreas copper and manganese homeostasis. Such responses may serve as early biomarkers of physiological changes occurring during the initial stages of cadmium intoxication.

KW - cadmium

KW - copper

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KW - dietary exposure

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