Abstract
| Original language | English |
|---|---|
| Journal | Environmental Toxicology and Pharmacology |
| Early online date | 28 Oct 2018 |
| DOIs | |
| Publication status | E-pub ahead of print - 28 Oct 2018 |
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Bibliographical note
© 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/Keywords
- cadmium
- copper
- manganese
- iron
- dietary exposure
- land snails
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Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective. / Nica, Dragos V.; Draghici, George A.; Andrica, Florina-maria; Popescu, Sofia; Coricovac, Dorina E.; Dehelean, Cristina A.; Gergen, Iosif I.; Kovatsi, Leda; Coleman, Michael D.; Tsatsakis, Aristidis.
In: Environmental Toxicology and Pharmacology, 28.10.2018.Research output: Contribution to journal › Article
TY - JOUR
T1 - Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective
AU - Nica, Dragos V.
AU - Draghici, George A.
AU - Andrica, Florina-maria
AU - Popescu, Sofia
AU - Coricovac, Dorina E.
AU - Dehelean, Cristina A.
AU - Gergen, Iosif I.
AU - Kovatsi, Leda
AU - Coleman, Michael D.
AU - Tsatsakis, Aristidis
N1 - © 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
PY - 2018/10/28
Y1 - 2018/10/28
N2 - The available information on the interplay between low-dose cadmium intake and copper, manganese, and iron homeostasis in invertebrates is limited. We have currently studied the accumulation of these trace metals in the hepatopancreas of adult snails, Cantareus aspersus, following 14 and 28 days of exposure to low doses of dietary cadmium, up to 1 mg/kg dw (dry weight). The cadmium dose, but not the duration of exposure, had a significant effect on hepatopancreas copper deposition, the values being significantly elevated compared to controls. A significant peak in manganese levels at 14 days was found in snails administered the lowest cadmium dose. These increases occurred even in the absence of cadmium increase in the hepatopancreas. Our data suggest that low dose cadmium feeding can produce a transient disturbance in hepatopancreas copper and manganese homeostasis. Such responses may serve as early biomarkers of physiological changes occurring during the initial stages of cadmium intoxication.
AB - The available information on the interplay between low-dose cadmium intake and copper, manganese, and iron homeostasis in invertebrates is limited. We have currently studied the accumulation of these trace metals in the hepatopancreas of adult snails, Cantareus aspersus, following 14 and 28 days of exposure to low doses of dietary cadmium, up to 1 mg/kg dw (dry weight). The cadmium dose, but not the duration of exposure, had a significant effect on hepatopancreas copper deposition, the values being significantly elevated compared to controls. A significant peak in manganese levels at 14 days was found in snails administered the lowest cadmium dose. These increases occurred even in the absence of cadmium increase in the hepatopancreas. Our data suggest that low dose cadmium feeding can produce a transient disturbance in hepatopancreas copper and manganese homeostasis. Such responses may serve as early biomarkers of physiological changes occurring during the initial stages of cadmium intoxication.
KW - cadmium
KW - copper
KW - manganese
KW - iron
KW - dietary exposure
KW - land snails
UR - https://linkinghub.elsevier.com/retrieve/pii/S1382668918305453
U2 - 10.1016/j.etap.2018.10.005
DO - 10.1016/j.etap.2018.10.005
M3 - Article
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
SN - 1382-6689
ER -