Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective

Dragos V. Nica, George A. Draghici, Florina-maria Andrica, Sofia Popescu, Dorina E. Coricovac, Cristina A. Dehelean, Iosif I. Gergen, Leda Kovatsi, Michael D. Coleman, Aristidis Tsatsakis

Research output: Contribution to journalArticle

Abstract

The available information on the interplay between low-dose cadmium intake and copper, manganese, and iron homeostasis in invertebrates is limited. We have currently studied the accumulation of these trace metals in the hepatopancreas of adult snails, Cantareus aspersus, following 14 and 28 days of exposure to low doses of dietary cadmium, up to 1 mg/kg dw (dry weight). The cadmium dose, but not the duration of exposure, had a significant effect on hepatopancreas copper deposition, the values being significantly elevated compared to controls. A significant peak in manganese levels at 14 days was found in snails administered the lowest cadmium dose. These increases occurred even in the absence of cadmium increase in the hepatopancreas. Our data suggest that low dose cadmium feeding can produce a transient disturbance in hepatopancreas copper and manganese homeostasis. Such responses may serve as early biomarkers of physiological changes occurring during the initial stages of cadmium intoxication.
Original languageEnglish
JournalEnvironmental Toxicology and Pharmacology
Early online date28 Oct 2018
DOIs
Publication statusE-pub ahead of print - 28 Oct 2018

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Gastropoda
Manganese
Cadmium
Copper
Homeostasis
Iron
Hepatopancreas
Snails
Biomarkers
Invertebrates
Metals
Weights and Measures

Bibliographical note

© 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

  • cadmium
  • copper
  • manganese
  • iron
  • dietary exposure
  • land snails

Cite this

Nica, Dragos V. ; Draghici, George A. ; Andrica, Florina-maria ; Popescu, Sofia ; Coricovac, Dorina E. ; Dehelean, Cristina A. ; Gergen, Iosif I. ; Kovatsi, Leda ; Coleman, Michael D. ; Tsatsakis, Aristidis. / Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective. In: Environmental Toxicology and Pharmacology. 2018.
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Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective. / Nica, Dragos V.; Draghici, George A.; Andrica, Florina-maria; Popescu, Sofia; Coricovac, Dorina E.; Dehelean, Cristina A.; Gergen, Iosif I.; Kovatsi, Leda; Coleman, Michael D.; Tsatsakis, Aristidis.

In: Environmental Toxicology and Pharmacology, 28.10.2018.

Research output: Contribution to journalArticle

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AU - Nica, Dragos V.

AU - Draghici, George A.

AU - Andrica, Florina-maria

AU - Popescu, Sofia

AU - Coricovac, Dorina E.

AU - Dehelean, Cristina A.

AU - Gergen, Iosif I.

AU - Kovatsi, Leda

AU - Coleman, Michael D.

AU - Tsatsakis, Aristidis

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Y1 - 2018/10/28

N2 - The available information on the interplay between low-dose cadmium intake and copper, manganese, and iron homeostasis in invertebrates is limited. We have currently studied the accumulation of these trace metals in the hepatopancreas of adult snails, Cantareus aspersus, following 14 and 28 days of exposure to low doses of dietary cadmium, up to 1 mg/kg dw (dry weight). The cadmium dose, but not the duration of exposure, had a significant effect on hepatopancreas copper deposition, the values being significantly elevated compared to controls. A significant peak in manganese levels at 14 days was found in snails administered the lowest cadmium dose. These increases occurred even in the absence of cadmium increase in the hepatopancreas. Our data suggest that low dose cadmium feeding can produce a transient disturbance in hepatopancreas copper and manganese homeostasis. Such responses may serve as early biomarkers of physiological changes occurring during the initial stages of cadmium intoxication.

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