Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective

Dragos V. Nica, George A. Draghici, Florina-maria Andrica, Sofia Popescu, Dorina E. Coricovac, Cristina A. Dehelean, Iosif I. Gergen, Leda Kovatsi, Michael D. Coleman, Aristidis Tsatsakis

Research output: Contribution to journalArticlepeer-review


The available information on the interplay between low-dose cadmium intake and copper, manganese, and iron homeostasis in invertebrates is limited. We have currently studied the accumulation of these trace metals in the hepatopancreas of adult snails, Cantareus aspersus, following 14 and 28 days of exposure to low doses of dietary cadmium, up to 1 mg/kg dw (dry weight). The cadmium dose, but not the duration of exposure, had a significant effect on hepatopancreas copper deposition, the values being significantly elevated compared to controls. A significant peak in manganese levels at 14 days was found in snails administered the lowest cadmium dose. These increases occurred even in the absence of cadmium increase in the hepatopancreas. Our data suggest that low dose cadmium feeding can produce a transient disturbance in hepatopancreas copper and manganese homeostasis. Such responses may serve as early biomarkers of physiological changes occurring during the initial stages of cadmium intoxication.
Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalEnvironmental Toxicology and Pharmacology
Early online date28 Oct 2018
Publication statusPublished - Jan 2019

Bibliographical note

© 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International


  • cadmium
  • copper
  • manganese
  • iron
  • dietary exposure
  • land snails


Dive into the research topics of 'Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective'. Together they form a unique fingerprint.

Cite this