Signal Transduction Pathways in Ageing

Cathy Slack, Jennifer Tullet

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

It is now widely recognised that ageing and its associated functional decline are regulated by a wide range of molecules that fit into specific cellular pathways. Here, we describe several of the evolutionary conserved cellular signalling pathways that govern organismal ageing and discuss how their identification, and work on the individual molecules that contribute to them, has aided in the design of therapeutic strategies to alleviate the adverse effects of ageing and age-related disease.

Original languageEnglish
Title of host publicationBiochemistry and Cell Biology of Ageing: Part I Biomedical Science
PublisherSpringer
Chapter11
Pages323-350
Number of pages28
Volume90
ISBN (Electronic)978-981-13-2835-0
ISBN (Print)978-981-13-2834-3
DOIs
Publication statusPublished - 19 Feb 2019

Publication series

NameSub-cellular biochemistry
ISSN (Print)0306-0225

Keywords

  • AMPK
  • Ageing
  • Insulin signalling
  • Ras/MAPK
  • mTOR

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  • Cite this

    Slack, C., & Tullet, J. (2019). Signal Transduction Pathways in Ageing. In Biochemistry and Cell Biology of Ageing: Part I Biomedical Science (Vol. 90, pp. 323-350). (Sub-cellular biochemistry). Springer. https://doi.org/10.1007/978-981-13-2835-0_11