Abstract
It is now widely recognised that ageing and its associated functional decline are regulated by a wide range of molecules that fit into specific cellular pathways. Here, we describe several of the evolutionary conserved cellular signalling pathways that govern organismal ageing and discuss how their identification, and work on the individual molecules that contribute to them, has aided in the design of therapeutic strategies to alleviate the adverse effects of ageing and age-related disease.
| Original language | English |
|---|---|
| Title of host publication | Biochemistry and Cell Biology of Ageing: Part I Biomedical Science |
| Publisher | Springer |
| Chapter | 11 |
| Pages | 323-350 |
| Number of pages | 28 |
| Volume | 90 |
| ISBN (Electronic) | 978-981-13-2835-0 |
| ISBN (Print) | 978-981-13-2834-3 |
| DOIs | |
| Publication status | Published - 19 Feb 2019 |
Publication series
| Name | Sub-cellular biochemistry |
|---|---|
| ISSN (Print) | 0306-0225 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- AMPK
- Ageing
- Insulin signalling
- Ras/MAPK
- mTOR
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