Silencing of CDKN1C (p57KIP2) is associated with hypomethylation at KvDMR1 in Beckwith-Wiedemann syndrome

Keyphrases

• Hypomethylation 100%
• Beckwith-Wiedemann Syndrome 100%
• KvDMR1 100%
• CDKN1C 100%
• P57Kip2 100%
• Methylation 62%
• Loss of Methylation 37%
• Quantitative PCR 25%
• Ribonuclease Protection Assay 25%
• Non-associated 12%
• Southern Hybridization 12%
• Steady State 12%
• Restriction Endonuclease 12%
• Gene Expression 12%
• Fibroblast Cells 12%
• Cell Culture 12%
• Cell-derived 12%
• Expression Level 12%
• Potential Consequences 12%
• Multiple Genes 12%
• Promoter Region 12%
• Culture-based 12%
• Epigenetic Mechanisms 12%
• Hypermethylation 12%
• Targeted Deletion 12%
• Epimutation 12%
• 11p15.5 12%
• CpG Island 12%
• Chromosome 11p15 12%
• Imprinted Gene Expression 12%
• Chromatin Insulator 12%
• Genetic Mechanism 12%
• Enhancer Blocking 12%
• Silencer 12%
• KCNQ1 Gene 12%
• Imprinting Control Region 12%
• Southern Analysis 12%
• Blocking Assay 12%

Biochemistry, Genetics and Molecular Biology

• Methylation 100%
• Beckwith-Wiedemann Syndrome 100%
• Gene Expression 25%
• Promoter Region 25%
• Real-Time Polymerase Chain Reaction 25%
• Ribonuclease 25%
• Southern Blotting 12%
• Allele 12%
• Downregulation 12%
• Fibroblast 12%
• Cell Culture 12%
• Steady State 12%
• Epigenetic Mechanism 12%
• Enhancer Region 12%
• Restriction Modification System 12%
• Epimutation 12%
• CpG Island 12%
• Genetic Mechanism 12%